The growing literature on the rapid eye movement (REM) sleep behaviour disorder (RBD)–neurodegenerative disease association continues to provide insights into normal and abnormal neurological functioning, particularly in the synucleinopathies.1 The Braak staging scheme for the Parkinson's disease (PD) ...
“biomarker”, “disease modification”, “early diagnosis”, “treatment monitoring”, “motor symptoms”, “non-motor symptoms”, “neurodegeneration”, “Parkinson’s disease”, “precision medicine”, “stratification”, “symptomatic treatment”, “synucleinopathies”, “telehealth”, “wearables”...
This study suggested RBD as a unique subpopulation that will allow future early intervention for synucleinopathies.(Krohn L et al. medRxiv 2021.09.08.21254232). 2.1.3. Curated GWAS unravelling novel genetic pathways GWAS meta-analyses with a larger sample size were well-powered to identify ...
These interventional neuroradiological procedures are performed in a min- imally invasive way, in close coordination with other specialists, such as neurosurgeons, neurologists or orthopaedic surgeons, to name but a few. The list of diseases that can affect the brain is long and diverse. This ...
such as Aβ [24] (in Alzheimer's disease), tau [25] (in numerous neurodegenerative diseases), prions [26] (in transmissible spongiform encephalopathies), alpha-synuclein [27] (in synucleinopathies, including Parkinson's disease) and superoxide dismutase 1 [28] (in amyotrophic lateral sclerosi...
(in transmissible spongiform encephalopathies), alpha-synuclein [27] (in synucleinopathies, including Parkinson’s disease) and superoxide dismutase 1 [28] (in amyotrophic lateral sclerosis). Exosomes have thus been suggested to be propagators of neurodegenerative protein spread, although some cargos ...
In AD transgenic mice, changes in the gut microbiome have been shown to alter amyloid deposition in the brain [39,40]. PD and other synucleinopathies are characterized by the aggregation of α-synuclein protein (αSyn) overexpression in mice, which results in motor dysfunction. It has been ...
In candidate gene studies, single-nucleotide polymorphisms (SNPs) in SCARB2 (rs6812193) and MAPT (rs12185268) were significantly associated with RBD.[15] RBD patients who carried the USP25 SNP rs2823357 converted to a-synucleinopathies faster than who did not.[15] Patients with PD who carried...
were considered separately. Parkinson's disease is also a very common cause of dementia that, together with Lewy body dementia (a progressive disease with prominent extrapyramidal movements) and multiple system atrophy (a progressive neurodegenerative disorder), constitute the so-called synucleinopathies....
Having access to multiple wellヽharacterized and validated cellular models is essential not only for advancing our understanding of the biology of α㏒yn and PD but also to identify novel therapeutic targets and drugs that could be successfully developed into treatments for PD and synucleinopathies...