Does idiopathic REM sleep behavior disorder (iRBD) really exist? What are the potential markers of neurodegeneration in iRBD?REM sleep behavior disorderNeurodegenerationα-SynucleinopathiesMarkersOlfactionAutonomic functionREM sleep behavior disorder (RBD) may be idiopathic or associated with other ...
“biomarker”, “disease modification”, “early diagnosis”, “treatment monitoring”, “motor symptoms”, “non-motor symptoms”, “neurodegeneration”, “Parkinson’s disease”, “precision medicine”, “stratification”, “symptomatic treatment”, “synucleinopathies”, “telehealth”, “wearables”...
Researchers are continuing their pursuit in 2024 to study active and passive immunotherapy approaches with the goal of modifying the spread of α-synuclein pathology in the brain in patients with PD. According to a review previously published in the journalNeurotherapeutics,1currently available treatments...
Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade? Abnormal accumulation of proteinaceous intraneuronal inclusions called Lewy bodies (LBs) is the neurpathological hallmark of Parkinson's disease (PD) and r... O Abid - 《Journal ...
These interventional neuroradiological procedures are performed in a min- imally invasive way, in close coordination with other specialists, such as neurosurgeons, neurologists or orthopaedic surgeons, to name but a few. The list of diseases that can affect the brain is long and diverse. This ...
This study suggested RBD as a unique subpopulation that will allow future early intervention for synucleinopathies.(Krohn L et al. medRxiv 2021.09.08.21254232). 2.1.3. Curated GWAS unravelling novel genetic pathways GWAS meta-analyses with a larger sample size were well-powered to identify ...
(APOE4) alleles are considered significant risk factors, not only for tauopathies such as AD but also for the development of dementia in synucleinopathies; PD strongly impacts the neurotropism of the SARS-CoV-2 virus (glial cells and neurons expressing ACE2 receptors) and the severity of CO...
Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies. Am. J. Pathol. 2006, 168, 947–961. [Google Scholar] [CrossRef] [Green Version] Sang, Q.; Liu, X.; Wang, L.; Qi, L.; Sun, W.; Wang, W.; Sun, Y.; Zhang...
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were considered separately. Parkinson's disease is also a very common cause of dementia that, together with Lewy body dementia (a progressive disease with prominent extrapyramidal movements) and multiple system atrophy (a progressive neurodegenerative disorder), constitute the so-called synucleinopathies....