Alpha-synuclein pathology and axonal degeneration of the peripheral motor nerves inner- vating pharyngeal muscles in Parkinson disease. J Neuropathol Exp Neurol 2013;72:119e29.Mu L, Sobotka S, Chen J, et al. Alpha-synuclein pathology and axonal degeneration of the peripheral motor nerves ...
astrocytes and microglia, in line with the active inflammatory process in the substantia nigra in patients with PD37. Further, we provide evidence that the worsening in brain pathology over time impacts the whole neurovascular unit, as evidenced by the compromised BBB permeability. When taken togethe...
In particular, the hypothesis that aSyn is secreted from neurons, thus contributing to the spreading of pathology not only in the brain but also in other organs, is gaining momentum. Nevertheless, the precise mechanism(s) of secretion, as well as the consequences of extracellular aSyn species ...
Alpha-synuclein is the main constituent of intra-neuronal Lewy bodies, which are characteristic of Parkinson's disease, but aggregates are also found as axonal inclusions. Alpha-synuclein pathology is found together with betaamyloid plaques and neurofibrillary tangles in Alzheimer's disease and other ...
acta neuropathol commun (2021) 9:31 https://doi.org/10.1186/s40478-021-01131-8 RESEARCH Open Access Trans‑synaptic spreading of alpha‑synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain Nelson Ferreira1*† , Nádia Pereira...
alpha-Synuclein: a potent inducer of tau pathology 来自 Semantic Scholar 喜欢 0 阅读量: 38 作者: J Geddes 摘要: Spinal Cord and Brain Injury Research Center and Sanders-Brown Center on Aging, University of Kentucky, 800 South Limestone Street, Lexington, KY 40536-0230, USA. jgeddes@uky.edu...
incomplete proteolytic cleavage of extracellular αSyn seems to exacerbate αSyn pathology35,36. Here, we provide evidence that αSyn lacking either the N- or the C-terminus leads to neurotoxicity. Hence, it is necessary to carefully approach the modulation of proteolytic activity as a therapeutic...
Despite Aβ or α-synuclein pathology in the current animal models, no difference was observed in the extent of drug transport across the BBB compared to wild type animals for any of the compounds investigated. Hence, the present study shows that the concept of a leaking barrier within ...
it will be important to perform patient-specific molecular pathology based on high-resolution structural analysis of aSyn aggregates in different areas of the brain, to understand the origin of these different aggregate structures and how they affect the function of neurons, astrocytes, oligodendrocytes...
Induction of CNS [alpha]-synuclein pathology by fibrillar and non-amyloidogenic recombinant [alpha]-synuclein [alpha]S brain inclusions also are present in a spectrum of neurodegenerative disorders known as [alpha]-synucleinopathies [1, 2, 3]. A direct causal... AN Sacino,M Brooks,NH Mcgarve...