Alpha-synuclein pathology and axonal degeneration of the peripheral motor nerves innervating pharyngeal muscles in Parkinson disease. J Neuropathol Exp Neurol. 2013; 72:119-129. [PubMed: 23334595]Mu L, Sobotka S, Chen J, et al. Alpha-synuclein pathology and axonal degeneration of the peripheral ...
incomplete proteolytic cleavage of extracellular αSyn seems to exacerbate αSyn pathology35,36. Here, we provide evidence that αSyn lacking either the N- or the C-terminus leads to neurotoxicity. Hence, it is necessary to carefully approach the modulation of proteolytic activity as a therapeutic...
astrocytes and microglia, in line with the active inflammatory process in the substantia nigra in patients with PD37. Further, we provide evidence that the worsening in brain pathology over time impacts the whole neurovascular unit, as evidenced by the compromised BBB permeability. When taken togethe...
α-Synuclein (A-syn) plays a pivotal role both in the development of the disease and propagation of the pathology in Parkinson’s disease (PD). Levels of total A-syn in cerebrospinal fluid (CSF) can discriminate PD from controls or tauopathies as groups. However, it is hard to diagnose ...
1. Mitochondrial dysfunction and alpha-synuclein pathology in Parkinson's Disease 2. From physiology to pathology: alpha-synuclein interactions with (mitochondrial) membranes 3. Consequences of the interaction of alpha-synuclein with mitochondria 4. Modulation of alpha-synuclein pathology and mitochondrial ...
The neuroanatomical distribution of each cell-type specific α-syn pathology was evaluated using conditional probability matrices and Subtype and Stage Inference (SuStaIn) algorithm. We revealed extensive glial α-syn pathology in LBD, emphasizing the disease- and region-specific profile of astrocytic α...
The tight association between α-Syn and the molecular pathology of PD has generatly increaed the interest in using the α-Syn species as biomarkers to diagnose early PD. α-Syn is not confined to the central nervous system, it is also present in the peripheral tissues, such as human ...
A53T mutation [31,33,34], whereas no consistent αsyn pathology has been reported in tau transgenic mice or FTDP-17 T patients [66]. However, this is somewhat contradicted by the observation that αsyn pathology in AD is more pronounced than the tau pathology in PD [16,22–24,26–29,...
Analysis of postmortem PD brains show increased inflammatory markers, including increases in cells immunoreactive for ionized calcium binding adaptor molecule 1 (Iba1), human leukocyte antigen (HLA-DR), and phagocytic marker CD68 in the vicinity of Lewy pathology, specifically the substantia nigra (SN...
To elucidate whether the a-syn pathology spreads through neural circuits in the brain, recombinant mouse a-syn PFFs (Additional file 1: Figure S1) were injected as “seeds” into the right dorsal striatum of C57BL/6J mice. Immunohistological methods were then used to examine in detail the ...