协议内容包括合作开发用于治疗包括帕金森在内的α-突触核蛋白病(Alpha-synuclein, α-syn)的双抗药物ABL301。ABL301采用ABL专有的Grabody-B平台技术,能够有效跨越血脑屏障,是一款处于临床前阶段的“first-in-class”双抗,能够靶向α-突触核蛋白和IGF1R。 帕金森等疾病面临的挑战 α-syn主要表达于神经元的突触前末...
别名:Alpha Synuclein Protein, AlphaSyn Protein, NACP Protein, Non A4 component of amyloid Protein, PARK1 Protein, PARK4 Protein, SNCA Protein, SYN Protein, Parkison disease familial 1 Protein研究领域:神经纤维缠结&Tau, 突触核蛋白, 神经生物学, 神经衰退疾病, 帕金森氏病, 阿尔茨海默病...
Aggregation of alpha-synuclein (αSyn) is a crucial event underlying the pathophysiology of synucleinopathies. The existence of various intracellular and extracellular αSyn species, including cleaved αSyn, complicates the quest for an appropriate thera
Syn 202 抗原 Recombinant human alpha- and beta-synuclein. 偶联物 Unconjugated 形式 Liquid 浓度 0.5 mg/mL 纯化类型 Protein A 保存液 PBS, pH 7.4 内含物 0.1% sodium azide 保存条件 -20°C 运输条件 Ambient (domestic); Wet ice (international) RRID AB_253309...
别 名:Alpha synuclein; Alpha-Synuclein; Alpha-synuclein, isoform NACP140; alpha SYN; MGC105443; MGC110988; MGC127560; MGC64356; NACP; Non A beta component of AD amyloid; Non A4 component of amyloid precursor; Non-A-beta component of alzheimers disease amyloid , precursor of; Non-A be...
Define Alpha synuclein. Alpha synuclein synonyms, Alpha synuclein pronunciation, Alpha synuclein translation, English dictionary definition of Alpha synuclein. n. A polypeptide protein found primarily in brain neurons but seen also in the fibrils in Park
(PMN). Moreover, axonal degeneration after overexpression ofαSyn-WT and -A30P was analyzed by live imaging in the rat optic nervein vivo. We found that overexpression ofαSyn-WT and of its mutants A30P and A53T impaired neurite outgrowth of PMN and affected neurite branching assessed by ...
Alpha Synuclein (α-syn) is a 14-19 kDa phosphoprotein that is primarily localize to the presynaptic terminals of mature neurons, where it is involved in synaptic function and plasticity. Α-syn has drawn intense interest ever since the late 1990s, when the first α-synuclein missense mutation...
Both α-Synuclein (αSyn) accumulation and mitochondrial dysfunction have been implicated in the pathology of Parkinson’s disease (PD). Altho
α-Syn Alpha-synuclein Parkinson's disease Biomarker Skin Biopsy 1. Introduction Parkinson's disease (PD), the second most common neurodegenerative disease after Alzheimer's disease, is the leading neurodegenerative movement disorder worldwide [1]. It affects 0.2% of the population globally and impos...