Then, the mice were euthanized for tissue harvesting. CD8+ T cell depletion was conducted by intraperitoneal injection of InVivoMAb anti-mouse CD8α (200 µg/mouse; BE0061, BioXCell) every three days for a total of six times, starting three days after tumor cell inoculation. The tumor ...
The concept of intratumoural microbiota was subsequently proposed. Microbiota could colonise tumour tissues through mucosal destruction, adjacent tissue migration, and hematogenic invasion and affect the biological behaviour of tumours as an important part of the tumour microenvironment. Mechanistic studies ...
Krukenberg tumor is a rare metastatic tumor of the ovary with histopathological features known as signet ring cells. It usually develops in women around 45 years of age. However, here we describe an uncommon case in a 38-year-old pregnant woman. We
The tumor microenvironment (TME) is comprised of non-malignant cells that interact with each other and with cancer cells, critically impacting cancer biology. The TME is complex, and understanding it requires simplifying approaches. Here we provide an experimental-mathematical approach to decompose the...
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Inflammation and kidney function markers resulted within the normal range. Complete results of the tests are reported in Supplementary Table 2. The clinical presentation was suggestive of rhabdomyolysis and fluid therapy was immediately started. The successive exams were performed to make differential ...
Co-administration of gentamicin with another compound, the negatively charged poly-L-aspartic acid (PAA), was shown to protect rats against the development of kidney nephrotoxicity (Gilbert et al., 1989; Ramsammy et al., 1989). It has been suggested that PAA, similarly to daptomycin, binds ...
A total of 79 differentially expressed proteins (DEPs) were identified when CDH and control lungs were compared, and further bioinformatics analysis showed that these proteins play important roles in tight-junctions, phospholipase D signaling, and the HIF-1 signaling pathway. Three differentially expres...
Longitudinal CD45-PET imaging further enables precise monitoring of dynamic changes in tissue-specific inflammatory profiles. Finally, we developed a human CD45-PET probe for clinical translation that effectively detects human immune cells in a humanized mouse model. CD45-PET imaging holds substantial ...
of cells within the myocardial tissue5. These developmental abilities also translate into a regenerative role. Adult zebrafish hearts are capable of regeneration, and developmental epicardial genes become highly expressed at the infarcted region, coinciding with the restoration of cardiac muscle6,7. ...