On the other hand, recent single-cell/single-nucleus RNA-sequencing (sc/snRNA-seq) studies of primary disease have demonstrated that GBM cells exhibit a high degree of plasticity at the phenotypic level and apparent transitions between cellular states6,7,8,9; however, it is unknown to what ex...
human cell atlasliver cancersingle cell RNAseqspatial transcriptomicstumor‐stroma interactionsMalignant cell growth is fueled by interactions between tumor cells and the stromal cells composing the tumor microenvironment. The human liver is a major site of tumors and metastases, but molecular identities ...
皮肤细胞(Spinous Cells):标记基因为KRT10(角蛋白10)。 颗粒细胞(Granular Cells):标记基因为FLG(角蛋白基因)。 内皮细胞(Endothelial Cells):标记基因为VWF(von Willebrand因子)。 免疫细胞(Immune Cells):标记基因为CD207(Langerin)。 纤维母细胞(Fibroblasts):标记基因为COL1A1(胶原蛋白1A1)和COL3A1(胶原蛋白3...
Fig. 2: A single-cell atlas of human LN BECs. a, UMAP plot of MFLN BECs coloured according to classification of arterial, capillary and venous BECs.b, The proportions of arterial, capillary and venous BECs in MFLN samples.c, Expression levels of arterial, capillary and venous BEC marker ...
We integrated these datasets with previous single-cell chromatin accessibility data from 15 fetal tissue types to reveal the status of open chromatin for ∼1.2 million candidate cis-regulatory elements (cCREs) in 222 distinct cell types comprised of >1.3 million nuclei. We used these chromatin ...
et al. A human breast atlas integrating single-cell proteomics and transcriptomics. Dev. Cell https://doi.org/10.1016/j.devcel.2022.05.003 (2022). Twigger, A. J. et al. Transcriptional changes in the mammary gland during lactation revealed by single cell sequencing of cells from human milk...
Here we present a single-cell and spatially resolved transcriptomics analysis of human breast cancers. We developed a single-cell method of intrinsic subtype classification (SCSubtype) to reveal recurrent neoplastic cell heterogeneity. Immunophenotyping using cellular indexing of transcriptomes and epitopes ...
A comparative atlas of single-cell chromatin accessibility in the human brain 发表期刊和时间:Science,13 October 2023 Lab:Bing Ren, 实验室正在研究正常和癌症细胞的基因调节机制,与路德维希研究所和加州大学合作密切。 摘要:探索了三名成年人42个大脑区域110万个细胞的开放染色质景观。整合这些数据揭示了107种...
Human-resident microbes can influence both health and disease. Investigating the microbiome using next-generation sequencing technology has revealed examples of mutualism and conflict between microbes and humans. Comparing to bacteria, the viral componen
Although single-cell RNA sequencing studies have begun to provide compendia of cell expression profiles1–9, it has been difficult to systematically identify and localize all molecular cell types in individual organs to create a full molecular cell