A phase 1 clinical trial of vorinostat in combination with decitabine in patients with acute myeloid leukaemia or myelodysplastic syndrome. Br J Haematol. 2014; 167(2):185-93. doi: 10.1111/bjh.13016 PMID: 25040094Kirschbaum M, Gojo I, Goldberg SL, et al. A phase 1 clinica...
Clinical phase I study on NC-6004 R Plummer et al 594 CH3O-(CH2CH2O)n-CH2CH2CH2-NH-(CO-CH-NH)m-x-(CO-CH-NH)x-H PEG-pGlu CH2 CH2 C OO CH2 CH2 C O O NH3 Pt NH3 Cisplatin residue Figure 1 Structure of cisplatin-PEG-poly(glutamic acid) block co-polymer conjugate. PEG-pGlu,...
WASHINGTON, June 2 (Xinhua) -- Ivosidenib, an experimental drug that inhibits a protein often mutated in several cancers, has been shown to be safe in a Phase I clinical trial, resulting in durable remissions, according to a study published on Saturday in the New England Journal of Medicine...
To overcome this limitation, we conducted a phase I clinical study of peptide vaccines designed for cancer patients with six different HLA-A types. Eligible patients were required to have failed prior standard cancer therapies and to be positive for the HLA-A2, -A24 or -A3 (A3, A11, A31 ...
There were two parts to this study. In Part 1, a dose-escalation strategy using the two-step adaptive Bayesian continual reassessment method (CRM)13 was used to determine the MTD and the recommended dose to be taken forward in Part 2, a dose expansion phase, to explore the OBD. OBD init...
Finally, we conducted in vitro and in vivo preclinical studies as well as a clinical phase I study in healthy volunteers to compare the biological, pharmacodynamic, pharmacokinetic and safety profile of BK0023 and Neupogen®. The results demonstrated the pharmacodynamic equivalence and the ...
1Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle WA, USA 翻译:付星 摘要 从1941年Huggins和Hodges提出前列腺癌是雄激素依赖的重要认识以来,抗雄激素治疗(androgen deprivation therapy, ADT)一直是转移性...
OBJECTIVE: This phase I study of ZYAN1 was conducted to evaluate the safety, tolerability, and pharmacokinetics following oral administration in healthy volunteers. METHODS: The study was a randomized, double-blind, placebo-controlled phaseI study carried out in two parts in addition to a third ...
The fate of camptothecin glycoconjugate: report of a clini- cal hold during a phase II study of BAY 56- 3722 (formerly BAY 38-3441), in patients ... SH Gelderblom - 《Investigational New Drugs》 被引量: 1发表: 2012年 The fate of camptothecin glycoconjugate: report of a clinical hold du...
Cocrystal Pharma, Inc. recently announced dosing of the first subjects in a Phase 1 clinical trial of healthy adults evaluating its novel, broad-spectrum, orally administered antiviralCC-42344for the treatment of pandemic and seasonal influenza A. The study is designed to assess the safety, tolerab...