A phase Ia clinical trial of LYM-1 monoclonal antibody serotherapy in patients with refractory B cell malignancies. Hematol Oncol. 1989;7:155-166.Hu E, Epstein AL, Naeve GS, et al. A phase 1a clinical trial of LYM-1 monoclonal antibody serotherapy in patients with refractory B cell ...
Codexis, Inc. recently announced top-line results from its Phase 1a single ascending-dose study in healthy volunteers with CDX-6114, its orally administered enzyme candidate for the potential treatment of the metabolic disorder phenylketonuria (PKU). All of the defined study endpoints were met. The...
Objective: To investigate the criteria, evaluation method and result judging of adverse events in the phase I clinical trial of tolerance to new drugs. Methods: Three kinds of new drugs , Propiverine hydioehloride, dimepiridc (A, B), were researched in the phase I clinical trial of tolera...
In summary, we present the first report of a phase I clinical trial using IMRCs to treat meniscus injury. Our results demonstrated that intra-articular injection of IMRCs is a safe and effective therapy by providing a permissive niche for cartilage regeneration....
To test the first of these hypotheses in a controlled setting, we have initiated a phase 1 clinical trial of IUHCT in fetuses with alpha thalassemia major (ATM), who already require a fetal intervention (in utero transfusions (IUT)) to survive the pregnancy. We present interim results from...
1a). The analysis presented here will focus on this osimertinib-relapsed cohort; however, the safety analysis will also include all 91 patients who received the amivantamab and lazertinib regimen in CHRYSALIS (combination cohort (n = 26), treatment-naive patients (n = 20) and the ...
fluorouracil14. A previous single-center clinical trial (NCT03159819) indicated that CT041 was well-tolerated and could be a promising therapy for patients with gastric and pancreatic cancers15. Therefore, we initiated an open-label, multicenter, single-arm, dose-escalation/de-escalation and dose-...
Maternal chimerism was detected in both patients, but levels were higher and persisted throughout the year only in patient 1 (Fig 1A). We detected 70-fold higher levels of erythrocyte precursors (Fig 1B) but normal levels of CD34+ cells in the cord blood of patients compared to healthy ...
7). We conducted a phase 1/2a clinical trial to evaluate the safety, pharmacokinetics and antiviral activity of up to six monthly infusions of PGT121, PGDM1400 and VRC07-523LS in PLWH. Results Study design and safety Part 1 of this phase 1/2a study was a single-center, open-label ...
Clinical trial The study was a phase 1 dose-escalation study of combination dacomitinib and osimertinib for patients with metastatic EGFR-mutant lung cancer. The study was approved by the Memorial Sloan Kettering Institutional Review Board; the study design and conduct complied with all required regula...