Notably, this STING–PERK–eIF2α pathway is evolutionarily primitive and physiologically critical to cellular senescence and organ fibrosis. Pharmacologically or genetically targeting this non-canonical cGAS–STING pathway attenuated lung and kidney fibrosis. Collectively, the findings identify an alternative...
The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the settings of infection, cellular stress and tissue damage. Underlying this broad involvement of the cGAS–STING pathway is its capacity to sense and regulate the cellu
A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA VaccinesIt has been known since the discovery of DNA vacciNSTL... - 《Journal of Immunology Official Journal of the American Association of Immunologists》 被引量: 0发表: 2016年 Induction of robust cellular and humoral virus...
摘要: Overactivation of the cGAS-STING pathway worsens acute pancreatitis but can reduce fibrosis and islet damage in chronic cases.Activating the cGAS-STING pathway can facilitatethe treatment of pancreatic cancer.Several cGAS-STING inhibitors and activators are in clinical trials....
high-energy meals mainly cause it. However, there is a lack of understanding of the etiology of the molecular mechanism of metabolic syndrome. The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is involved in various intestinal epithelial barrier dysfunctions and chronic...
However, the contribution of this pathway to the aging immune system remains largely unknown. Here, we highlight recent advances in understanding the biology of the cGAS-STING pathway, its influence on the senescence-associated secretory phenotype (SASP), and its modulation...
cGAS/STING pathway. For example, the long non-coding RNA (lncRNA) nuclear-enriched abundant transcript 1 (NEAT1) interacts with DNA methyltransferase (DNMT) enzymes 1 to promote the malignant biological behavior of lung cancer cells through methylation silencing of p53, cGAS, and STING [16]. ...
3A, ferrous ammonium citrate (FAC) was found to promote the expression of the Stimulator of Interferon Genes (STING) protein in a dose-dependent manner. Similar results were obtained by immunofluorescence staining (Fig. 3B). IL-1β has been reported to activate cGAS-STING pathway [18]. ...
Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 2015;11:1018–30. CAS PubMed PubMed Central Google Scholar Li T, Chen ZJ. The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer. ...
non-natural nucleotide monothiophosphates, MK-1454 is assembled diastereoselectively in a one-pot cascade, in which two thiotriphosphate nucleotides are simultaneously generated biocatalytically, followed by coupling and cyclization catalysed by an engineered animal cyclic guanosine-adenosine synthase (cGAS)...