Our suggestion for a common modular framework for gene set enrichment analysis methods is depicted in Fig.1. The scheme consists of five distinct modules: the calculation of a gene-level statistic, an optional transformation of these statistics, the choice of a null hypothesis, the computation of...
In one aspect, the method includes increasing a level of LOX activity in the tissue by e.g., administering to the subject a LOX/LOXL enhancer, e.g., a LOX or LOXL (e.g., a LOX or LOXL polypeptide, or active fragment thereof, or a nucleic acid encoding the polypeptide or active fr...
Despite the above evidence, the authenticity of the human strains has been doubted arguing with the high level of sequence conservation of BDVgenomes displaying less than 5% of divergence at the nucleotide level and less than 1% at the protein level. However, phylogenetic analyses claiming to ...
molecules Article Discovery of Matrinic Thiadiazole Derivatives as a Novel Family of Anti-Liver Fibrosis Agents via Repression of the TGFβ/Smad Pathway Tianyu Niu †, Weixiao Niu †, Yunyang Bao, Ting Liu, Danqing Song, Yinghong Li * and Hongwei He * Institute of Medicinal Biotechnology, ...
At the epigenetic level, response to salinity stress is classified into three histone modifications: acetylation, methylation, and phosphorylation. Under stringent saline conditions, histone acetylation is controlled by the antagonist action between the histone acetyl transferases (HATs) and histone deacetyla...
Plant mixtures may also exhibit an inverted U-shaped dose-effect curve of purification level vs. bioactivity, i.e., bioactivity increases up to a certain point in which the increase of the purity leads to the loss of some important compound, with the concomitant drop in bioactivity. Therefore...