defining the target prioritization landscape for 30 immune traits at the gene and pathway level. We demonstrate how our genetics-led drug target prioritization approach (the priority index) successfully identifies current therapeutics, predicts activity in high-throughput cellular screens (including L1000,...
44 The third locus is 22q13.31 with lead variant rs12160976 (β for A allele = −0.009, SE = 0.002, P = 1.6 × 10−8). Reproducibility of Depression-Associated Loci Although the lead variants of both novel associations from the meta-analyses of individuals of East ...
A single nucleotide polymorphism in the HBBP1 gene in the human β-globin locus is associated with a mild β-thalassemia disease phenotype. Hemoglobin 2012, 36, 433-445. [CrossRef] [PubMed]Giannopoulou E, Bartsakoulia M, Tafrali C, Kourakli A, Poulas K, Stavrou EF, Papachat...
Peanut (Arachis hypogaea L.) is an important allotetraploid oil and food legume crop. China is one of the world’s largest peanut producers and consumers. However, genomic variations underlying the migration and divergence of peanuts in China remain uncl
CUBN Is a Gene Locus for Albuminuria 喜欢 0 阅读量: 29 摘要: Identification of genetic risk factors for albuminuria may alter strategies for early prevention of CKD progression, particularly among patients with diabetes. Little is known about the influence of common genetic variants on albuminuria ...
the ED value of each single-nucleotide polymorphism (SNP) locus, the black line is the fitted ED value, the red dashed line represents the significant correlation threshold, and the red rectangle on the peak of chromosome 19 indicates the chromosomal peak that contained the candidate gene. ...
This observation can be explained after taking into consideration the fact that the TNFα gene is located at a locus (6p21.1–21.3) that has already been associated with genetic susceptibility to schizophrenia. Moreover, the complement system, a well-known part of the innate and adapted immune ...
Petersen, C., The gene product of the Plasmodium falciparum 11.1 locus is a protein larger than one megadalton, Molecular and biochemical Parasitology, 42:189-196, (1990).Petersen C, Nelson R, Leech J et al. The gene product of the Plasmodium falciparum 11.1 locus is a protein larger ...
the TNS within the Hox cluster does rise as high as 0.51 due to the gene expression correlation ofHoxa10andHoxa11combined with the fact that the entire locus is well conserved (see Figure4). Genome-wide analyses reveal that there are on the order of 100 neighborhoods with statistical signific...
Definition1910s:Geneasadistinctlocus Inthenextmajordevelopment,theAmericangeneticistThomasHuntMorganandhisstudentswerestudyingthesegregationofmutationsinDrosophilamelanogaster.Theywereabletoexplaintheirdatawithamodelthatgenesarearrangedlinearly,andtheirabilitytocross-overisproportionaltothedistancethatseparatedthem.Thefirst...