So, what it is the difference between a gene and an allele? The short answer is that an allele is a variant form of a gene. Explained in greater detail, each gene resides at a specific locus (location on a chromosome) in two copies, one copy of the gene inherited from each parent....
We used the resulting ~5.5 million SNPs with good post-imputation quality (Rsq>0.50) and minor allele frequency of at least 5%. Processing of samples analysed by illumina expression arrays Subdissected samples from cerebellar and frontal cortex samples originating from 390 control individuals were ...
However, the majority of cis-eQTLs do exhibit allele specific expression. We applied a linear model controlling for ancestry, sex, genotyping platform and latent factors12 in the expression data for each tissue that may reflect batch or other technical variables (see Methods; Extended Data Fig. ...
Heterozygous fish always mature later than those homozygous for the "earlier" allele. The site of action of the P locus could be the pituitary gland, the hypothalamus or higher centers of the brain where peripheral information is transduced into an appropriate signal required for the activation of...
The novel allele of the LhMYB12 gene is involved in splatter-type spot formation on the flower tepals of Asiatic hybrid lilies (Lilium spp.) The novel allele of the LhMYB12 gene is involved in splatter-type spot formation on the flower tepals of Asiatic hybrid lilies(Lilium spp.)[J]....
We found a splice-site mutation in a single individual, and we determined that, in six individuals, the mRNA from one COL5A1 allele either was not expressed or was very unstable. We identified small insertions or deletions in five of these cell strains, but we could not identify the ...
It can be a point mutation at a single locus, or a deletion, insertion, or rearrangement of a larger section of DNA. It only weakly affects allele frequencies, but is a major factor for introducing new alleles. Gene mutation is the ultimate source of genetic variability. Genes vary in ...
Protein Structure, TertiaryGene DosageHaplotypesPlant DiseasesGene Expression Regulation, PlantAmino Acid SequenceThe rhg1-b allele of soybean is widely used ... DE Cook,GL Tong,X Guo,... - 《Science》 被引量: 508发表: 2012年 Association of the SLC1A1 glutamate transporter gene and obsessive...
The CommonMind Consortium sequenced RNA from dorsolateral prefrontal cortex of people with schizophrenia (N = 258) and control subjects (N = 279), creating a resource of gene expression and its genetic regulation. Using this resource, ∼20% of schizophrenia loci have variants that could ...
We leveraged approximately 2.7 million SNPs with a minor allele frequency (MAF) > 0.05 in conjunction with the 45,545 genes exhibiting expression variation across all stages (64.8% of the predicted transcriptome) in the eQTL mapping (Supplementary Figs. 1 and 2). In total, 53,854 cis...