For example, controlling the false discovery rate FDR traditionally involves intricate sequential "p"-value rejection methods based on the observed data. Whereas a sequential "p"-value method fixes the error rate and "estimates" its corresponding rejection region, we propose the opposite approach-we...
Storey JD: A direct approach to false discovery rates. Journal of the Royal Statistical Society Series B (Methodological) 2002, 64: 479–498. 10.1111/1467-9868.00346 Article Google Scholar Bijlsma S, Bobeldijk I, Verheij ER, Ramaker R, Kochhar S, Macdonald IA, van Ommen B, Smilde AK:...
at the same time, to the multiple-testing problem. As an alternative to the too conservative Family-Wise Error-Rate (FWER), the False Discovery Rate (FDR) has appeared for the last ten years as more appropriate to handle
dysbiosis of the phyllosphere microbiota and consequently higher susceptibility of rice plants to disease. Our study provides a direct link between a specific plant metabolite and rice phyllosphere homeostasis opening possibilities for new breeding strategies. Similar content being viewed by others Phyllospher...
‘victim’, and (6) individual differences measured through self-report questionnaires. I applied a False Discovery Rate (FDR) approach with the Benjamini and Hochberg method40to each p-value for each of those correlations but for the sake of clarity these variables are reported in different ...
s false discovery rate while increases its true positive rate. For the challenge of scalability problems, we design an online algorithm for CS-Ranker (OLCS-Ranker) which trains PSM data samples one by one and uses an active set to keep only those PSMs effective to the discriminant function....
Second, it is important to apply the pi0 correction when estimating false discovery rates, that is estimate the prior probability of incorrect identification, see an example here. Of note, when estimating precursor-level FDR using this method, it is absolutely essential not to apply any kind of...
2. Plant-derived drug discovery: history, challenges, and significance 2.1. Natural products as drug candidates: a historical perspective The first written records on medicinal applications of plants date back to 2600 BC and report the existence of a sophisticated medicinal system in Mesopotamia, comp...
(Fig.3A). The GO term fusion was restricted to pV ≤ 0.005 that is based on the false discovery rate (Benjamini-Hochberg). The Ras-Raf-MAPK signaling pathway is a key route for the ErbB family, as is the PI3K/AKT pathway, both of which results in alteration of cell proliferation...
an open-source software that provides reliable dose-response characteristics by computingp-values and false discovery rates based on a recalibrated F-statistic and a target-decoy procedure that considers dataset-specific effect size distributions. The application of CurveCurator to three large-scale data...