Controlling mixed directional false discovery rate in multidimensional decisions with applications to microarray studiesArticleTime-course microarray experiments harvested samples at several time points. To reveal the dynamic gene expression changes over time, we need to identify the significant genes and ...
Multidimensional local false discovery rate for microarray studies. Motivation: The false discovery rate (fdr) is a key tool for statistical assessment of differential expression (DE) in microarray studies. Overall control ... A Ploner,S Calza,A Gusnanto,... - 《Bioinformatics》 被引量: 183...
177 was used to analyze the expression data using the DESeq function174,177, which transforms read counts based on the estimation of size factors and dispersion, fits to a negative binomial GLM, performs a Wald significance test, and assesses based on a cutoff false discovery rate of <0.05 ...
False discovery rate (FDR) analysis was performed against decoy reversed sequences generated from the respective protein databases. The threshold for determining confident protein identifications was set at a 95% confidence cut-off (corresponding to <1% FDR) and at least one peptide identified. ...
(TPRs), false discovery rates (FDRs), and the F1 scores for: (i) detection of skeleton edges (i.e., without direction); and (ii) detection of directed edges between continuous and binary nodes. Power (or TPR) is calculated as the ratio between the number of correctly identified edges ...
To further validate mAb specificity, full-length hANKRD1 was expressed inE. colifrom its synthetic cDNA cloned into pJ404. Directional insertion of this cDNA into 5’ Not I and 3’ Sal I sites of the eukaryote expression vector, pCMV-Myc, positioned the hANKRD1 sequence downstream of the ...
1b. False discovery rate (FDR) adjusted P value <0.05. Also see conventional, uncorrected P value map in Fig. 1d). We also found that this vertical alignment tended to repeat in the horizontal direction with roughly regular interval (∼15 μm), which was clearly observed in one-...