The tumor microenvironment (TME) is comprised of non-malignant cells that interact with each other and with cancer cells, critically impacting cancer biology. The TME is complex, and understanding it requires simplifying approaches. Here we provide an experimental-mathematical approach to decompose the...
Termed here neutrotime, this spectrum extends from immature pre-neutrophils, largely in bone marrow, to mature neutrophils predominantly in blood and spleen. The sharpest increments in neutrotime occur during the transitions from pre-neutrophils to immature neutrophils and from mature marrow neutrophils ...
Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of abnormal blood vessels supplying the tumor. It has been reported that tumor hypoxia can: activate angiogenesis, t...
In the current study, despite increased pTregs in IRX4204-treated recipients, GVL responses against 2 aggressive tumor models were not lost at the tumor cell doses we tested. Data from previous studies have suggested that there is a threshold difference in donor T-cell responses that mediate ...
Immune cells account for the remarkable percentage of the whole tumor tissue. Among them, macrophages, namely TAMs, stand for one of the most plentiful stromal compositions in the TIME [13]. It is generally recognized that TAMs derive from circulating bone marrow monocytes which infiltrate the pri...
Glioma is a primary aggressive brain tumor with high recurrence rate. The poor efficiency of chemotherapeutic drugs crossing the blood‒brain barrier (BBB) is well-known as one of the main challenges for anti-glioma therapy. Moreover, massive infiltrated tumor-associated macrophages (TAMs) in gli...
The prevalence of kidney diseases is emerging as a public health problem. Stem cells (SCs), currently considered as a promising tool for therapeutic application, have aroused considerable interest and expectations. With self-renewal capabilities and grea
(additional file 1 : table s21). this is not surprising given the known role of senescence in tumor suppression. some cs genes were also shared between many of the ard classes. these results are in line with a previous analysis investigating the relationship between cs and ard genes ...
Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the human lung, but their spatial context is less well defined. To (re)define tissue architecture of lung and airways, we profiled five proximal-to-distal locations of healthy human lungs in depth using multi...
re-forming appropriate connections in vivo in adults following transplantation is challenging given the need for long peripheral projections to muscles. Adult stem cells have not provided sustained functional improvement in patients with ALS to date6. An early phase 2 trial using adult bone marrow-der...