One such mediator of dormancy is myeloid derived suppressor cells (MDSC), whose number in the peripheral blood (PB) or infiltrating tumors has been associated with cancer stage, grade, patient survival, and metastasis in a broad range of tumor pathologies. Thus, extensive studies have revealed a...
The immunoregulatory role of bone marrow: I. Suppression of the induction of antibody responses to T-dependent and T-independent antigens by cells in the bone marrow. Cell Immunol. 1979;43:362–71. Article CAS PubMed Google Scholar Ribechini E, Greifenberg V, Sandwick S, Lutz MB. ...
At present, cytotoxic drugs are generally applied for postoperative adjuvant therapy or advanced CRC patients, usually accompanied by a series of adverse effects (such as constipation, diarrhea, nausea, and bone marrow suppression) and individual differences in drug efficacy [14, 15]. In recent year...
Cytotoxic drugs (drugs that are toxic to cells) are aimed at rapidly proliferating cells and interfere with nucleic acid and protein synthesis in the cancer cell, but they are often toxic to normal rapidly proliferating cells, such as bone marrow and hair cells. Often a combination of cytotoxic...
A potent inhibitor of tumor metastasis, Prosaposin (Psap), acts via stimulation of p53 and the anti-tumorigenic TSP-1 in bone marrow-derived cells that are recruited to metastatic sites5,6. Within the TME, TSP-1 has been shown to act on two key receptors CD36 and CD47 (4,5). As ...
Refractory metastatic rhabdomyosarcoma is largely incurable. Here we analyze the response of a child with refractory bone marrow metastatic rhabdomyosarcoma to autologous HER2 CAR T cells. Three cycles of HER2 CAR T cells given after lymphodepleting chem
are another main effector cell population contributing to the desmoplasia. The originations of CAFs in pancreatic cancer include resident fibroblast, bone marrow derived cells, and PSCs [36]. Resident fibroblasts express α-SMA but do not express neural markers, such as nestin and GFAP, which is...
This clinical trial examines the safety, efficacy, and biosimilarity of MW032 compared with denosumab in patients with solid tumor–related bone metastases.
Except for inflammation-associated cancers, MDSC is also reported to have a role in hematologic tumorigenesis. MDSC is found to drive bone marrow hematopoietic abnormalities, manifesting as multilineage cytopenias and cytological dysplasia. An increasing in the secretion of IL-10 and TGF-β by MDSC ...
Sanz L, Santos-Valle P, Alonso-Camino V et al (2008) Long-term in vivo imaging of human angiogenesis: critical role of bone marrow-derived mesenchymal stem cells for the generation of durable blood vessels. Microvasc Res 75(3):308–314...