Masc protein is a nuclear protein, but the mechanism underlying the transport of this protein into the nucleus has not yet been elucidated. Here, we identified a functional bipartite nuclear localization signal ( NLS) located between residues 274 and 290 of the Masc protein. Sequence comparison ...
CONCLUSION: Based on these data it is suggested that during HBV infection the final import of the genome complex into the nucleus is mediated by a novel bipartite NLS localized in the TP domain of HBV polymerase.OBJECTIVE: To determine the methods for establishing an in vivo model of long-...
Basic residues 315 to 330 confer partial nuclear localization on the bacterial protein beta-galactosidase. A bipartite signal consisting of this basic region in conjunction with either the second or third zinc finger, but not the first, suffices to target beta-galactosidase exclusively to the ...
Identification of a functional bipartite nuclear localization signal in the tumor suppressor parafibromin. Oncogene 24: 6241-6248, 2005. Hanahan D and Weinberg RA. The hallmarks of cancer. Cell. 100: 57-70, 2000.Hahn MA, Marsh DJ (2005) Identification of a functional bipartite nuclear ...
3.4. A bipartite nuclear localization signal identified in the N-terminus of SMC6 To assess the NLSs prediction capacity of cNLS Mapper to identify importin α binding proteins, we selected two of the candidates identified in this study. One of these, structural maintenance of chromosomes 6 (SM...
Identification and functional characterization of a bipartite nuclear localization signal in ANKRD11 Biochem. Bioph. Res. Co., 670 (2023), pp. 117-123 View PDFView articleView in ScopusGoogle Scholar [30] T.T. Zhang, Y. Yang, X.L. Yin, X.Q. Wang, J.H. Ni, Z.Y. Dong, et al...
A classical bipartite nuclear localization signal on Thogoto and influenza A virus nucleoproteins. Virology 250(1), 9 (1998). 19. Cros, J. F., Garcia-Sastre, A. & Palese, P. An unconventional NLS is critical for the nuclear import of the influenza A virus nucleoprotein and ...
Here it is shown that the cytoplasmic tail of CD43 contains a functional bipartite nuclear localization signal directing it to the nucleus. The intracellular domain of CD43 interacts with β-catenin and causes an upregulation of the β-catenin target genes c-MYC and CyclinD1. The present ...
Interplay between the exonic CA-rich element and upregulated SRSF3 facilitated the inclusion of MBNL1 exons 5 and 7, which encode a bipartite nuclear localization signal (NLS) and conformational NLS. Moreover, abundant SRSF3 interfered with the autoregulatory mechanism involved in utilization of ...
(MATR3) is a highly conserved component of the nuclear matrix [29–31]. MATR3 is a 125 kDa protein that contains a bipartite nuclear localization signal (NLS), two zinc finger domains, and two canonical RNA recognition motifs (RRM) [32]. Little is known about the function of MATR3. A...