Classical nuclear localization signals: definition, function, and interaction with importin alpha. J Biol Chem 282, 5101-5105.Lange A, Mills RE, Lange CJ, Stewart M, Devine SE, Corbett AH. Classical nuclear localization signals: definition, function, and interaction with importin alpha. J Biol ...
Importin α Nuclear Localization Signal Binding Sites for STAT1, STAT2, and Influenza A Virus Nucleoprotein. Proteins actively transported into the nucleus via the classical nuclear import pathway contain nuclear localization signals (NLSs), which are recognized b... Melén,Krister,Fagerlund,... - ...
The importin-α/β complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. Although Ran has been implic... D Gorlich - 《Journal of Cell Biology》 被引量: 1662发表: 1997年 Molecular basis for the recognition of a nonclassical nuclear localiza...
nuclear localization signal NPC: nuclear pore complex RBD: Ran-binding domain TMR: tetramethylrhodamine : 239–247 ArticleCASGoogle Scholar Hood JK and Silver PA (1999) In or out? Regulating nuclear import.Curr. Opin. Cell Biol.11: 241–247 ArticleCASGoogle Scholar Allen RG and Tresini M. (...
H5N1: Influenza A virus subtype H5N1 MXA: Myxovirus resistance gene A NLS: Nuclear localization signal NT: Nuclear transfer ORF: Open reading frame References Haller O, Staeheli P, Kochs G. Interferon-induced Mx proteins in antiviral host defense. Biochimie. 2007;89(6-7):812–8. ...
Nuclear protein import proceeds through the nuclear pore complex (NPC). Importin- mediates translocation via direct interaction with NPC components and car... Kutay,U. - 《Embo Journal》 被引量: 253发表: 2014年 The monopartite nuclear localization signal of autoimmune regulator mediates its nuclear...
Fig. 2. The extended RGG/RG motif in the N-terminal domain of the RV2 LANA homologs functions as a nuclear and nucleolar localization signal. Vero cells were transfected with plasmids encoding different RRV and MneRV2 LANA N-terminal peptide sequence fusions with the EGFP2 dimer to determine...
J. et al. PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression. Mol. Cell. Biol. 28, 3281–3289 (2008). 41. Chan, C. H. et al. Posttranslational regulation of Akt in human cancer. Cell Biosci. 4, 59 (2014). 42. Parker, R., ...
Recruitment of immune cells to the tumor microenvironment with active cell death is an ideal condition for phagocytic clearance of apoptotic bodies by phagocytes. However, the dying tumor cells must overcome eat-me signal-activated phagocytes to undergo metastasis or to survive. This can be achieved...
Normally, SPP is responsible for cleaving off the signal peptide of proteins that are targeted to the ER lumen via the Sec61 translocon complex. It was demonstrated that SPP and TRC8 interact not only in the presence but also in the absence of US2, suggesting that these molecules could ...