In this pathway, a protein containing a classical basic nuclear localization signal (NLS) is imported by a heterodimeric import receptor consisting of the beta-karyopherin importin beta, which mediates interactions with the nuclear pore complex, and the adaptor protein importin alpha, which directly ...
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the dying tumor cells must overcome eat-me signal-activated phagocytes to undergo metastasis or to survive. This can be achieved by the “fuse-to-me” signals exposed to dying tumor cells. In blebbishield emergency
Human adipose depots are functionally distinct. Yet, recent single-nucleus RNA sequencing (snRNA-seq) analyses largely uncovered overlapping or similar cell-type landscapes. We hypothesized that adipocyte subtypes, differentiation trajectories and/or intercellular communication patterns could illuminate this ...
Fig. 2. The extended RGG/RG motif in the N-terminal domain of the RV2 LANA homologs functions as a nuclear and nucleolar localization signal. Vero cells were transfected with plasmids encoding different RRV and MneRV2 LANA N-terminal peptide sequence fusions with the EGFP2 dimer to determine...
So far, a protein called GRP58 has been reported to contain an ER retention signal as well as Nuclear Localization Signal (NLS) but their function as well as mechanism are not clearly understood [26]. Such ER retention sequence was not found in Orc2 homologue of any other apicomplexan, ...
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HLA-E, unlike other MHC class Ib molecules is transcribed in virtually all human tissues and cell lines, although at lower levels than MHC class Ia (Braud et al., 1997; Wei and Orr, 1990) and bind nonamer peptides derived from other HLA class I signal sequences with a high restricted...
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A-C. Representative images of adipocytes displaying positive signal for the different markers used to identify the different adipocytes subpopulations (PDE4D (A); SKAP1 (B); ANK2 (C)) taken from additional patients, with an additional zoomed out images to illustrate prevalence and localization. ...