(89)Zr-labeled nivolumab for imaging of T-cell infiltration in a humanized murine model of lung cancer. Eur J Nucl Med Mol Imaging. 2018; 45: 110-20.England CG, Jiang D, Ehlerding EB, Rekoske BT, Ellison PA, Hernandez R, et al. (89)Zr-labeled nivolumab for imaging of T-cell ...
Nivolumab is a fully human IgG4 anti-PD-1 monoclonal antibody (mAb) approved for the treatment of advanced melanoma and advanced squamous non-small cell lung cancer. This study reports the preparation and in vivo evaluation of 89Zr-nivolumab in healthy non-human primates (NHP) as a baseline ...
Cole EL, Kim J, Donnelly DJ, Smith RA, Cohen D, Lafont V, Morin PE, Huang RY-C, Chow PL, Hayes W Jr (2017) Radiosyn- thesis and preclinical PET evaluation of 89Zr-nivolumab (BMS- 936558) in healthy non-human primates. Bioorg Med Chem 25(20):5407-5414. https://doi.org/...
PD-L1 detection using 89Zr-atezolizumab immuno-PET in renal cell carcinoma tumorgrafts from a patient with favorable nivolumab responseKidney cancer, Renal cancer, Immuno-PET, PD-L1, PD-1, PDX, Patient-derived xenograft, IO, Immunotherapy, Immune checkpoint inhibitors, Predictive biomarkers, SABR,...