89Zr-pembrolizumab tumor uptake was higher in patients with a response to pembrolizumab treatment but did not correlate with PD-L1 or PD-1 immunohistochemistry.doi:10.2967/jnumed.121.261926Anna-Larissa N. NiemeijerDaniela E. Oprea-LagerMarc C. Huisman...
PEMBROLIZUMAB DESFERRIOXAMINE ZIRCONIUM ZR-89,来源于药化词典-药智数据
11,12 In part B, PET imaging was carried out at the optimal pembrolizumab dose and day of imaging as determined in part A. When feasible, a tumor biopsy was carried out in part B shortly after the day 7 PET scan. Participation in the 89Zr-pembrolizumab PET imaging study was followed ...
89Zr-pembrolizumab imaging as a non-invasive approach to assess clinical response to PD-1 blockade in cancer BACKGROUND :Programmed cell death protein-1 (PD-1) antibody treatment is standard of care for melanoma and non-small cell lung cancer (NSCLC). Accurately p... IC Kok,JS Hooiveld,PPV...
肿瘤89Zr-pembrolizumab 摄取与肿瘤反应(P 趋势 = 0.014)和无进展(P = 0.0025)和总生存期(P = 0.026)相关。89Zr-pembrolizumab 5 mg 的摄取在脾脏中最高,平均 SUV 平均值为 5.8(±SD 1.8)。在 Waldeyer 环、正常淋巴结和炎症部位也有89Zr-pembrolizumab 摄取。
Ann Oncol 丨 89 Zr-pembrolizumab 成像作为评估癌症中 PD-1 阻断的临床反应的非侵入性方法 关键词:PD-1;89 Zr-pembrolizumab 成像 背景:程序性细胞死亡蛋白-1(PD-1)抗体治疗是黑色素瘤和非小细胞肺癌(NSCLC)的标准治疗方法。目前无法准确预测哪些患者将受益。PD-1 抗体的肿瘤吸收和生物分布可能起作用。因此,我...
89Zr-N-sucDf-pembrolizumabCynomolgus monkeysMesenteric lymph nodesSpleen and tonsilsStandardized uptake values (SUVmean)Purpose Programmed cell death-1 receptor (PD-1) and its ligand (PD-L1) are the targets for immunotherapy in many cancer types. Although PD-1 blockade has therapeutic effects, the...