摘要 Ferroptosis is a form of cell death that has received considerable attention not only as a means to eradicate defined tumour entities but also because it provides unforeseen insights into the metabolic adaptation that tumours exploit to counteract phospholipid oxidation1,2. Here, we identify pro...
2024年2月1日,同济大学医学院王平课题组在Nature在线发表题为“7-Dehydrocholesterol dictates ferroptosis sensitivity”的最新论文,研究发现远端胆固醇合成途径中产生的中间甾醇7-DHC是一种新的铁死亡内源抑制因子,阐明了7-DHC依赖其5,7-不饱和双键的结构特性直接抑制磷脂过氧化的具体机制,提示甾醇与磷脂的过氧化在铁死...