5-HT_7 receptorinteraction of serotonin receptorsanxietydepressive behavioraggressive behaviorcatalepsyhibernationSerotonin, a brain neurotransmitter, acting via 14 types of serotonin (5-HT) receptors regulates different forms of both normal and pathological behavior. All 5-HT receptors (except for 5-HT3...
The 5-HT1 receptor class is composed of five receptors (5-HT1A, 5-HT1B, 5-HT1D, 5-ht1e and 5-HT1F) which, in humans, share 40–63% overall sequence identity and couple somewhat preferentially to G 5-HT2 receptors, a family of receptors coupled to Gq/11 There are three types ...
5-hydroxytryptamine receptor 5A (5-HT5A) belongs to the 5-HT receptor family and signals through the Gi/oprotein. It is involved in nervous system regulation and an attractive target for the treatment of psychosis, depression, schizophrenia, and neuropathic pain. 5-HT5Ais the only Gi/o-coupl...
1B,1C,1D,2 AND 3; Peroutka, 1988), among which the 5-HT1Asubtype has been the focus of intense research during the last few years. This receptor type is located both presynaptically on the 5-HT cell bodies (somatodendritic receptors), predominantly in the dorsal and median raphe nuclei ...
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neuron silencing to show that behavioural aggression, a behavioural function previously associated with the 5-HT system in general, can be modulated by small subsets of 5-HT neurons in the DR marked by intersectional expression of Pet1 and two different dopamine receptor genes, but not to others...
The 5-HT2A receptor is a type of receptor located on human chromosome 13q14-q21, responsible for mediating contractile responses in various smooth muscle tissues and playing a role in platelet aggregation and capillary permeability. AI generated definition based on:xPharm: The Comprehensive Pharmacolo...
本研究针对5-HT1A受体激活如何破坏大鼠母性行为这一科学问题,通过实时PCR和c-Fos免疫组化技术,揭示了妊娠期至产后阶段5-HT1A受体mRNA的动态表达模式,并阐明8-OH-DPAT急性/重复给药通过前/后突触差异机制影响伏隔核(NAc)、内侧前额叶皮层(mPFC)等关键脑区神经活动。该研究为理解5-HT系统调控母性行为的神经机制提供...
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