文章:《Single-Cell Transcriptomic Analysis of Tumor-Derived Fibroblasts and Normal Tissue-Resident Fibroblasts Reveals Fibroblast Heterogeneity in Breast Cancer》,在这个研究里面,作者 investigated CAF heterogeneity in triple-negative breast cancer (TNBC) using a syngeneic mouse model, BALB/c-derived 4T1 ma...
文章:《Single-Cell Transcriptomic Analysis of Tumor-Derived Fibroblasts and Normal Tissue-Resident Fibroblasts Reveals Fibroblast Heterogeneity in Breast Cancer》,在这个研究里面,作者 investigated CAF heterogeneity in triple-negative breast cancer (TNBC) using a syngeneic mouse model, BALB/c-derived 4T1 ma...
Both rAd.Null, and rAd.Light could replicate in human breast cancer cells, and produced cytotoxicity to human and mouse mammary tumor cells. rAd.Light induced apoptosis resulting in tumor cell death. Using a subcutaneous model of 4T1 cells in BALB/c mice, rAd.Light was delivered intratumoral...
Given the importance of microenvironment and tumor-host interactions in tumor cell behavior, this is not surprising. Syngeneic mouse models such as the 4T1 model described here also have the important advantage of allowing analyses to be carried out in animals with normal immune function. Because ...
In this study, we used a 4T1/BALB/c syngeneic TNBC mouse model, focusing on the association between Cav-1 and ITGα3. Most of our findings are from 4T1 cells in the BALB/c syngeneic breast cancer model. Our strategy involves utilizing the 4T1 TNBC mouse cell line to induce tumor deve...
Syngeneic models In syngeneic models, immortalized tumor cells originating from an inbred mouse strain are expanded in vitro and implanted into immunocompetent mice of the same strain. In breast cancer the most commonly used syngeneic models include the 4T1 (derived from the mammary gland of BALB/...
In contrast to other expe- rimental animal models in which tumor growth and pro- gression do not parallel their human counterparts, many characteristics of 4T1 tumors in syngeneic mice resemble those of human mammary carcinomas, making the 4T1 model suitable for studies of metastatic cancer [1,...
An improved syngeneic orthotopic murine model of human breast cancer progression[J]. Breast Cancer Res Treat, 2014,147(3):501. [28] Pulaski BA,Ostrand-Rosenberg S. Mouse 4T1 breast tu- mor model[J]. Curr Protoc Immunol,2001,doi:10.1002/ 0471142735.im2002s39. (收稿日期:2015-08-01 修...
In contrast to other expe- rimental animal models in which tumor growth and pro- gression do not parallel their human counterparts, many characteristics of 4T1 tumors in syngeneic mice resemble those of human mammary carcinomas, making the 4T1 model suitable for studies of metastatic cancer [1,...
c-MET is considered a driver of cancer progression, impacting tumor growth and tumor-supporting stroma. Here, we investigated the therapeutic efficacy of OMO-1, a potent and selective c-MET inhibitor, in an immunocompetent intraductal mouse model for tri