These findings, for the first time, provide scientific evidence that HACP can improve the immune response in 4T1 tumor-bearing mice, which plays a major role in the antitumor effect. Thus, HACP is prospectively valuable to be developed as new products with immunomodulatory activity and used for...
Vasilevska J, Skrastina D, Spunde K, Garoff H, Kozlovska T, Zajakina A: Semliki Forest virus biodistribution in tumor-free and 4 T1 mammary tumor-bearing mice: a comparison of transgene delivery by recombinant virus particles and naked RNA replicon. Cancer Gene Ther 2012, 19 : 579-...
combined with adriamycin on mouse breast cancer cell line 4T1.METHODS 4T1 tumor-bearing mice models were established by transplanting the 4T1 cells into BALB/c mice and were divided into four groups treated respectively with saline,adriamycin,Chuankezhi Injection and Chuankezhi Injection combined ...
The result was consistent with the tumor growth observations. It was preliminarily concluded that the proteins of Apriona swainsoni larvae have certain in-vivo anti-tumor effects, and they have no obvious toxic and side effects on the body and the main organs of the 4T1 tumor-bearing mice.Key...
荷瘤小鼠体重的影响 Fig.1 Effect of different treatment methods on body weight in 4T1 tumor-bearing mice 表1 不同处理方式对4T1 荷瘤小鼠给药前后体重的影响(mean±SEM) Table 1 Effect of different treatment methods on body weight before and after dosing in 4T1 tumor-bearing mice 注:*p<0.05 ...
Levels of IL-2, INF-γ and TNF-α in the blood serum of the 4T1-bearing mice.Qiuxian PengHongbing CaiXuegang SunXin LiZhixian MoJue Shi
A: The body weight curve of tumor-bearing mice.B: H-E staining of tumor-bearing mice 3 讨论 癌细胞迁移和侵袭是造成患者死亡的主要原因,因此寻找低毒、有效的药物抑制癌细胞迁移和侵袭是抗肿瘤研究的重点[21]。而乳腺癌病理...
1一bearingmice,andthephagocyticcapacityoftu— mor-associatedmacrophageswasdramaticallydecreased.Condusion:Tumor-associatedm acrophagesin4T1tumor-bearingBALB/emicernight bepolarizedtothealternativeactivationphenotype(M2). [Keywords]Tumor-associatedmacmphages;Ahemativelyactivatedmacrophages;Phago cyticcapacity 恶性肿瘤...
Effect on the survival time of tumor-bearing mice. Compared with TC, **P < 0.01. n = 10. Full size image Effects on the weight-loaded swimming test The anti-fatigue activity of the BZYQ was measured as the swimming endurance capacity of 4 T1 breast cancer mice. Change of swimming time...
Dey JH, Bianchi F, Voshol J, Bonenfant D, Oakeley EJ Hynes NE (2010) Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis. Cancer Res 70:4151- 4162. Dong F, Budhu AS, Wang XW (2009) Translating the ...