These findings, for the first time, provide scientific evidence that HACP can improve the immune response in 4T1 tumor-bearing mice, which plays a major role in the antitumor effect. Thus, HACP is prospectively valuable to be developed as new products with immunomodulatory activity and used for...
AIM To investigate the effect of Chuankezhi Injection(Epimedii Folium,Morindae officinalis Radix,etc.) combined with adriamycin on mouse breast cancer cell line 4T1.METHODS 4T1 tumor-bearing mice models were established by transplanting the 4T1 cells into BALB/c mice and were divided into four ...
The result was consistent with the tumor growth observations. It was preliminarily concluded that the proteins of Apriona swainsoni larvae have certain in-vivo anti-tumor effects, and they have no obvious toxic and side effects on the body and the main organs of the 4T1 tumor-bearing mice.Key...
图4 不同处理方式4T1 荷瘤小鼠肿瘤实物图 Fig.4 Tumor images of different treatment methods on 4T1 tumor-bearing mice 结合表2 可发现,阳性对照组肿瘤质量最小,斗米虫蛋白中剂量组次之,且与模型对照组相比,均有显著差异性(p<0.05),而中剂量组与阳性对照组相比,肿瘤质量无统计学差异性(p>0.05),表明斗...
A: The body weight curve of tumor-bearing mice.B: H-E staining of tumor-bearing mice 3 讨论 癌细胞迁移和侵袭是造成患者死亡的主要原因,因此寻找低毒、有效的药物抑制癌细胞迁移和侵袭是抗肿瘤研究的重点[21]。而乳腺癌病理...
1一bearingmice,andthephagocyticcapacityoftu— mor-associatedmacrophageswasdramaticallydecreased.Condusion:Tumor-associatedm acrophagesin4T1tumor-bearingBALB/emicernight bepolarizedtothealternativeactivationphenotype(M2). [Keywords]Tumor-associatedmacmphages;Ahemativelyactivatedmacrophages;Phago cyticcapacity 恶性肿瘤...
officinale water extract on tumor growth in tumor-bearing mice ( x s , n = 8～10) 模型 EPI DOE 0.5 g·kg−1 DOE 1.0 g·kg−1 DOE 1.5 g·kg−1 图 3 铁皮石斛水提物对荷瘤小鼠肿瘤组织病理变化的影响 (HE, ×200) Fig. 3 Effect of D. officinale water extract on tumor ...
Levels of IL-2, INF-γ and TNF-α in the blood serum of the 4T1-bearing mice.Qiuxian PengHongbing CaiXuegang SunXin LiZhixian MoJue Shi
Effect on the survival time of tumor-bearing mice. Compared with TC, **P < 0.01. n = 10. Full size image Effects on the weight-loaded swimming test The anti-fatigue activity of the BZYQ was measured as the swimming endurance capacity of 4 T1 breast cancer mice. Change of swimming time...
Splenomegaly has been associated with 4T1 tumor progression and leukemoid reactions15,16,18,19,20,21. Based on spleen weights, tumor-bearing mice receiving vehicle suffered from severe splenomegaly (Supplementary Fig.7a). Cisplatin either with or without OMO-1 significantly reduced splenomegaly compare...