产品描述 4EGI-1产品是4EGI-1 is an inhibitor of the interaction of translation initiation factor eIF4G to eIF4E. It inhibits the binding of eIF4G to eIF4E, but not 4E-BP1. The KD for eIF4E binding to 4EGI-1 is 25 μM ± 11 μM. It inhibits proliferation of human cancer cells. It...
4EGI-1 (eIF4E/eIF4G interaction inhibitor)4EGI-1 (see Fig. E9 ) inhibits complex formation between translation initiation factors eIF4E and eIF4G (Moerke NJ et al 2007 Cell 128:257). Figure E9.doi:10.1007/978-1-4020-6754-9_5129Springer NetherlandsSpringer Netherlands...
4EGI1Autophagy4EGI-1inhibitEukaryotic Initiation Factor (eIF)InhibitorApoptosis Related Tags: buy 4EGI-1 | purchase 4EGI-1 | 4EGI-1 cost | order 4EGI-1 | 4EGI-1 chemical structure | 4EGI-1 in vivo | 4EGI-1 formula | 4EGI-1 molecular weight...
eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, has been shown to amplify TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-induced apoptosis via down-regulation of FLIP|S/L|and induction of DR5. These characteristics of the compound seem to be independent of it′s ability to inhibit...
4EGI-1抑制eIF4E与eIF4G相互作用,作用于HNE1细胞72小时IC50值为50μM。注:本品仅可用于科研实验,严禁用于临床医疗及其他用途!CAS号:315706-13-9纯度:98.0%分子式:C18H12Cl2N4O4S分子量:451.28结构式:储存条件:-20℃,有效期2年,溶入溶剂后-20℃请尽量在一个月内使用。相关搜索:eIF4E与eIF4G相互作用抑制剂(...
4egi-1, a competitive eif4e/eif4 g interaction inhibitor, binds to eif4e(kd=25 μm). 价格:￥电议型 号:T2665产 地:中国大陆 T26654EGI-1;化合物4EGI-14EGI 1;4EGI 1 4egi-1, a competitive eif4e/eif4 g interaction inhibitor, binds to eif4e(kd=25 μm). ...
4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 μM. 4EGI-1 specifically inhibits the function of mTOR by blocking the activation of 4E-BP1. 4EGI-1 induces apoptosis
CAS号315706-13-9货号BCP28021 中文名4EGI-1 英文名4EGI-1 中文别名 英文别名4EGI1; 4EGI1; 4 EGI1; 4-EGI1; 4 EGI 1; 4-EGI-1; 分子式C18H12Cl2N4O4S分子量451.28 本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
4EGI-1结构式 常用名 4EGI-1 英文名 eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 CAS号 315706-13-9 分子量 451.28 密度 1.6±0.1 g/cm3 沸点 712.2±70.0 °C at 760 mmHg 分子式 C18H12Cl2N4O4S 熔点 N/A MSDS N/A 闪点 384.5±35.7 °C ...
In the present study, we investigated the in vitro activity of the cap-dependent translation inhibitor 4EGI-1 and its potential mechanism of action in both myeloma and primary myeloma cells, and we showed that 4EGI-1 effectively kills MM cells through Noxa induction. Materials and methods Human...