查看相关系列 mPGES1 Inhibitor Skip to the end of the images gallery Skip to the beginning of the images gallery 基本描述 别名 N-环戊基-1-[5,6-二甲基-1-(1-甲基乙基)-1H-苯并咪唑-2-基] -4-哌啶甲酰胺 规格或纯度 ≥98%(HPLC) 英文名称 C3 生化机理 选择性微粒体前列腺素E合酶1(...
These preliminary results show promise for the use of an mPGES-1 inhibitor in the treatment of AAA.Lauren M WeaverPharmaceutical Sciences, Univ of Kentucky, Lexington, KYMadeline J StewartPharmaceutical Sciences, Univ of Kentucky, Lexington, KYKai Ding...
and various inhibitors have been reported in the literature. However, none of the reported potent inhibitors of human mPGES-1 has shown to be also a potent inhibitor of mouse or rat mPGES-1, which prevents using
MF63是mPGES-1抑制剂,对猪mPGES-1和人mPGES-1的IC50分别为0.9nM和1.3nM。注:本品仅可用于科研实验,严禁用于临床医疗及其他用途!CAS号:892549-43-8纯度:99.47%分子式:C23H11ClN4分子量:378.81结构式:储存条件:-20℃,有效期2年,溶入溶剂后-20℃请尽量在一个月内使用。相关搜索:mPGES-1抑制剂(MF63),892549-...
本课题组前期在体实验发现肥胖小鼠体内抵抗素水平升高,升高的抵抗素可促进小鼠静脉血栓的形成,同时肥胖大鼠体内纤溶酶原激活剂抑制物-1(Plasminogen activator inhibitor1,PAI-1)水平也升高.紧接着本课题组前期体外实验发现抵抗素能促进内皮细胞PAI-1表达水平的升高.因此,综合体内外实验,我们推测抵抗素促进血栓形成的...
结论:MK886可抑制耐药白血病HL-60/A细胞增殖,诱导其凋亡,增强其化疗敏感性,其机制与下调mPGES-1/PGE2合成、抑制P-Akt蛋白及多药耐药基因表达有关。关键词mPGES-1;HL-60/A细胞;凋亡;耐药 中图分类号R733.71;R979.1文献标识码A Effect of mPGES-1Inhibitor MK886on Apoptosis and Drug Resistance of ...
By using the DREAM--CDM approach, lapatinib has been identified as a promising mPGES-1 inhibitor which may have significant anti-inflammatory effects to relieve various forms of pain and possibly treat various inflammation conditions involved in other inflammation-related diseases such as the lung ...
摘要 To investigate the effect of a microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor MK886 on cell cycle of the human acute myeloid leukemia HL-60 cells. HL-60 cells were treated with different concentration of MK886 (10,25,50 μmol/L) for 24 h. Flow cytometry, Wester...
MF63_MPGES-1抑制剂_892549-43-8_Apexbio
齐留通(zileuton)是目前唯一进入临床研究并作为处方药使用的5-LOX抑制剂(Lehnigk,B.;Rabe,K.F.;Dent,G.;Herst,R.S.;Carpentier,P.J.;Magnussen,H.,Effects of a5-lipoxygenase inhibitor,ABT-761,on exercise-induced bronchoconstriction and urinaryLTE4in asthmatic patients.Eur.Respir.J.1998,11(3),617...