Macrophage activationType 1 diabetesPancreatic beta cell dysfunction and activated macrophage infiltration are early features in type 1 diabetes pathogenesis. A tricarboxylic acid cycle metabolite that can strongly activate NF-E2-related factor 2 (Nrf2) in macrophages, itaconate is important in a series ...
Activated macrophages switch from oxidative phosphorylation to aerobic glycolysis, similar to the Warburg effect, presenting a potential therapeutic target in inflammatory disease. The endogenous metabolite itaconate has been reported to regulate macroph
The mechanism of release involves type I IFN-induced caspase-11 which promotes macrophage pyroptosis. Here we find that F3 is a type I IFN-stimulated gene. Furthermore, F3 induction by lipopolysaccharide (LPS) is inhibited by the anti-inflammatory agents dimethyl fumarate (DMF) and 4-octyl ...
Inflammatory bowel disease (IBD) is a complex gastrointestinal condition marked by immune system dysfunction and intestinal barrier damage. The pathogenesis involves a mix of genetic, environmental, and immunological factors, with the potential for itaconic acid derivatives like 4-Octyl itaconate (4-OI)...
4-octyl ItaconateMacrophages are involved in the early inflammation during tissue repair and play a distinctive role in maintaining the stability of the tissue microenvironment. However, it is still very difficult to accurately regulate the phenotypic transformation of macrophages during bone repair. The...
Interpretation: 4‐OI could effectively inhibit NLRP3 signaling, leading to the inhibition of proinflammatory cytokine production in patients with NMOSD‐derived PBMCs and in a human macrophage model. Thus, 4‐OI and itaconate could have important therapeutic value for the treatment of NMOSD ...
The mechanism of release involves type I IFN-induced caspase-11 which promotes macrophage pyroptosis. Here we find thatF3is a type I IFN-stimulated gene. Furthermore,F3induction by lipopolysaccharide (LPS) is inhibited by the anti-inflammatory agents dimethyl fumarate (DMF) and 4-octyl itaconate ...
The cell-permeable itaconate analog 4-octyl itaconate (4-OI) provides protection against inflammatory responses and oxidative stress. However, whether 4-OI can protect against ALI remains poorly understood. The aim of this study was to explore the protective effects of 4-OI against LPS-...
Fig. 2: 4-Octyl-itaconate (4-OI) and dimethyl fumarate (DMF) inhibit SARS-CoV2 replication. (a–f)hTMPRSS2-Vero cells treated with 4-OI (48 h) and infected with SARS-CoV-2 (48 h). Viral replication by qPCR (a,b), TCID50-assay (c–e) or plaque assay (f). Are pooled...
4-OI restrained inflammation by reducing macrophage infiltration and suppressing the expression of IL-1尾 and NLRP3 in the septic kidney. 4-OI also reduced ROS levels, as well as cleaved caspase-3 and boosted antioxidants such as HO-1, and NQO1 in mice. In addition, the 4-OI treatment ...