4-Octyl Itaconate 是一种可透过细胞的 Itaconate 衍生物。Itaconate 是一种抗炎代谢产物,通过 KEAP1 的烷基化而活化 Nrf2。 MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务 生物活性 体内研究 4-辛酯伊塔酸酯(OI)是一种可渗透细胞的伊塔酸酯衍生物。Itaconate 4-辛酯在体内对脂多糖...
Itaconate 是一种抗炎代谢产物,通过 KEAP1 的烷基化而活化 Nrf2。 生物活性:4-Octyl Itaconate 是一种具有细胞渗透性的衣康酸酯衍生物。衣康酸盐是一种抗炎代谢物,可通过 KEAP1[1]的烷基化激活Nrf2。 IC50 和目标:Nrf2[1]体内:4-Octyl Itaconate (OI) 是一种细胞渗透性衣康酸酯衍生物。 4-Octyl Itaconate...
4-Octyl itaconate (4-OI), derived from itaconic acid, effectively permeates cell membranes, showcasing potent anti-inflammatory as well as antioxidant effects in several disease models. Our study aimed to investigate the effect of 4-OI on cisplatin-induced ferroptosis and the underlying mo...
Itaconate 是一种抗炎代谢产物,通过 KEAP1 的烷基化而活化 Nrf2。 生物活性:4-Octyl Itaconate 是一种具有细胞渗透性的衣康酸酯衍生物。衣康酸盐是一种抗炎代谢物,可通过 KEAP1[1] 的烷基化激活Nrf2。 IC50 和目标:Nrf2[1]体内:4-Octyl Itaconate (OI) 是一种细胞渗透性衣康酸酯衍生物。 4-Octyl Itacona...
生物活性:4-Octyl Itaconate 是一种具有细胞渗透性的衣康酸酯衍生物。衣康酸盐是一种抗炎代谢物,可通过 KEAP1[1]的烷基化激活Nrf2。 IC50 和目标:Nrf2[1]体内:4-Octyl Itaconate (OI) 是一种细胞渗透性衣康酸酯衍生物。 4-Octyl Itaconate 在体内可防止脂多糖诱导的致死性,并减少细胞因子的产生[1]。
4-Octyl Itaconate 是一种可透过细胞的 Itaconate 衍生物。Itaconate 是一种抗yan代谢产物,通过 KEAP1 的烷基化而活化 Nrf2。
MCE 国际站:4-Octyl itaconate 产品活性:4-Octyl Itaconate 是一种可透过细胞的 Itaconate 衍生物。Itaconate 是一种抗炎代谢产物,通过 KEAP1 的烷基化而活化 Nrf2。 研究领域:NF-κB 作用靶点:Keap1-Nrf2 In Vivo: 4-Octyl Itaconate (OI) is a cell-permeable itaconate derivative. 4-Octyl Itaconate is pr...
Activated macrophages switch from oxidative phosphorylation to aerobic glycolysis, similar to the Warburg effect, presenting a potential therapeutic target in inflammatory disease. The endogenous metabolite itaconate has been reported to regulate macroph
4-OI and itaconate have been shown to have a range of anti-inflammatory effects, including activation of the transcription factor NRF229, and inhibition of NLRP330, glycolysis32, TET DNA dioxygenases33, and the kinase JAK134. Some of these effects such as NRF2 activation35 and inhibition of...
4-Octyl itaconate (4-OI), a derivative of itaconate, inhibits inflammation by alkylating its target proteins. Here, we present a click-chemistry-based protocol for detecting 4-OI-alkylated proteins in mouse primary bone-marrow-derived macrophages (BMDMs) by using an itaconate-alkyne (ITalk) probe...