4-Octyl Itaconate 是一种可透过细胞的 Itaconate 衍生物。Itaconate 是一种抗炎代谢产物,通过 KEAP1 的烷基化而活化 Nrf2。 MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务 生物活性 体内研究 4-辛酯伊塔酸酯(OI)是一种可渗透细胞的伊塔酸酯衍生物。Itaconate 4-辛酯在体内对脂多糖...
4-Octyl Itaconate 是一种可透过细胞的 Itaconate 衍生物。Itaconate 是一种抗炎代谢产物,通过 KEAP1 的烷基化而活化 Nrf2。 MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务 生物活性 体内研究 4-辛酯伊塔酸酯(OI)是一种可渗透细胞的伊塔酸酯衍生物。Itaconate 4-辛酯在体内对脂多糖...
4-octyl itaconate (4-OI) is an anti-inflammatory metabolite that activates the nuclear-factor-E2-related factor 2 (NRF2) signaling. In the current work, we investigated whether 4-OI could affect the production of proinflammatory cytokines in Behcet's uveitis (BU) and experimental autoimmune ...
4-Octyl Itaconate (4-OI) 是一种可渗透细胞的衣康酸酯衍生物。衣康酸酯和 4-Octyl Itaconate 具有相似的硫醇反应性,使 4-Octyl Itaconate 成为研究其生物学功能的合适的衣康酸酯替代物。据报道,4-Octyl Itaconate 可使 kelchlike ECH 相关蛋白 1 (KEAP1) 上的半胱氨酸残基烷基化,然后激活核因子(红细胞衍...
4-Octyl Itaconate 是一种可透过细胞的 Itaconate 衍生物。Itaconate 是一种抗yan代谢产物,通过 KEAP1 的烷基化而活化 Nrf2。
4-OI and itaconate have been shown to have a range of anti-inflammatory effects, including activation of the transcription factor NRF229, and inhibition of NLRP330, glycolysis32, TET DNA dioxygenases33, and the kinase JAK134. Some of these effects such as NRF2 activation35 and inhibition of...
Itaconate, an electrophilic α, β-unsaturated carboxylic acid has been reported to inhibit the inflammation responses in many cells.2It can alkylate protein cysteine residues by Michael addition to regulate the function of targeted proteins.34-Octyl itaconate (4-OI), a derivative of itaconate, also...
Fig. 2: 4-Octyl-itaconate (4-OI) and dimethyl fumarate (DMF) inhibit SARS-CoV2 replication. (a–f)hTMPRSS2-Vero cells treated with 4-OI (48 h) and infected with SARS-CoV-2 (48 h). Viral replication by qPCR (a,b), TCID50-assay (c–e) or plaque assay (f). Are pooled...
As a derivative of itaconate with high cell membrane permeability, 4-octyl itaconate (4-OI) could provide a protective effect for various diseases. However, the role of 4-OI in renal IRI is still unclear. Herein, we examined whether 4-OI afforded kidney protection through atte...
4-Octyl Itaconate 是一种可透过细胞的 Itaconate 衍生物。Itaconate 是一种抗炎代谢产物,通过 KEAP1 的烷基化而活化 Nrf2。 MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务 生物活性 体内研究 4-辛酯伊塔酸酯(OI)是一种可渗透细胞的伊塔酸酯衍生物。Itaconate 4-辛酯在体内对脂多糖...