4-Octyl Itaconate 是一种可透过细胞的 Itaconate 衍生物。Itaconate 是一种抗炎代谢产物,通过 KEAP1 的烷基化而活化 Nrf2。 4-Octyl Itaconate is a cell-permeable Itaconate derivative. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 ...
4-Octyl Itaconate is a cell-permeable derivative of Itaconate, an anti-inflammatory metabolite. 4-Octyl Itaconate activates Nrf2 via alkylation of KEAP1 and also inhibits phosphorylation of STING. 4-Octyl Itaconate is an anti-inflammatory metabolite. ...
NOVEL ITACONATE DERIVATIVE ATTENUATES ISOPROTERENOL INDUCED CARDIOTOXICITY IN EXPERIMENTAL ANIMALS: A MOLECULAR PATHWAY INSIGHTdoi:10.1097/01.hjh.0001021216.23687.014-octyl itaconate (4-OI) is a potential drug for the treatment of myocardial infarction on account of its potent anti-inflammatory, antioxidant...
Four-octyl itaconate (4-OI) is the cell-permeable derivative of itaconate that can activate Nrf2 signaling by alkylating Keap1's cysteine residues. Here, we tested the potential effect of 4-OI on hydrogen peroxide (HO)-induced oxidative injury in osteoblasts. In OB-6 cells and primary murine...
4-Octyl Itaconate详情 评价(0) 货号:ajce47538 CAS:3133-16-2 别名:4-辛基衣康酸 分子式:C13H22O4 分子量:242.31 纯度:>98% 溶解度:DMSO : ≥ 150 mg/mL (619.04 mM) 储存:Store at -20°C 库存:现货 Background 4-Octyl Itaconate (4-OI) is a cell-permeable itaconate derivative. Itaconate...
5 mM0.083 ml0.413 ml0.825 ml Last Update:2024-01-02 23:10:35 Itaconate -Uses and synthesis methods Target Nrf2 In vivo studies 4-Octyl Itaconate (OI) is a cell-permeable itaconate derivative. 4-Octyl Itaconate is protective against lipopolysaccharide-induced lethality in vivo and decreases cytok...
4-Octyl itaconate (4-OI), a cell-permeable derivative of itaconate, blocks the activation of the NLRP3 inflammasome and IL-1β release as well as inhibits STING expression and PI3K/Akt signaling [22,51,52]. Additionally, itaconate derivatives can directly modify and inhibit JAK1 [25]. Anoth...
4-Octyl Itaconate 是一种可透过细胞的 Itaconate 衍生物。Itaconate 是一种抗yan代谢产物,通过 KEAP1 的烷基化而活化 Nrf2。
To overcome the limitations of itaconate, 4-octyl itaconate (4-OI), a cell-permeable itaconate derivative, was synthesized. Itaconate and 4-OI had similar thiol reactivity, making 4-OI a suitable itaconate surrogate to study its biological function20. 4-OI is reported to alkylate cysteine ...
4-Octyl itaconate (4-OI), a cell-permeable derivative of itaconate, blocks the activation of the NLRP3 inflammasome and IL-1β release as well as inhibits STING expression and PI3K/Akt signaling [22, 51, 52]. Additionally, itaconate derivatives can directly modify and inhibit JAK1 [25]. ...