Dendritic cellsCo-stimulatory molecules4-1BB4-1BB signal has profound effects on T cell induced cell immune response, but its biological function on dendritic cells (DCs) has remained unknown. Here, we investigated the function of 4-1BB on murine DCs with an agonistic mAb to 4-1BB. IL-6...
Blocking both signal 1 and signal 2 of T-cell activation prevents apopto- sis of alloreactive T cells and induction of peripheral allograft tolerance. Nat Med 1999;5:1298-302 Lucas PJ, Negishi I, Nakayama K, Fields LE, Lo DY. Naïve CD28-deficient T cells can initiate but not sustain ...
Signal。研究结果显示CD28和4-1BB使用相同的信号通路,但是CD28活化引起的磷酸化水平显著高于4-1BB,也因此产生更高水平的效应分子,因而CD28CAR-T具有更强的细胞效应功能。但是同时CD28 CAR-T也表达更高水平的耗竭标志物,也可以解释其为何存留时间更短。 FYI:总结生物医药更多知识点,敬请关注公众平台「佰傲谷BioValley...
近日,上海交通大学医学院附属瑞金医院赵维莅教授及其团队在Signal Transduction and Targeted Therapy杂志上发表了一项突破性研究,揭示了通过双靶向PD-L1和4-1BB克服耐药的新机制,为FL的治疗带来了新的希望。 近年来,免疫调节剂来那度...
2025年1月,赵维莅教授在《Signal Transduction and Targeted Therapy》 【IF40.8,Q1】发表题名为“Dual targeting PD-L1 and 4-1BB to overcome dendritic cell-mediated lenalidomide resistance in follicular lymphoma.”——双重靶向...
Human 4-1BB (CD137), a member of the tumor necrosis factor receptor (TNFR) superfamily, costimulates T cell activation. No apparent intrinsic kinase activity is seen with 4-1BB, which suggests that 4-1BB-associated molecules may be involved in 4-1BB-mediated signal transduction. We found...
5.Benjamin I Philipson et al,4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling,Sci Signal . 2020 Mar 31;13(625):eaay8248. 6.Chester C, Sanmamed MF, Wang J, Melero I.Immunotherapy targeting 4-1BB: mechanistic rationale, clinical results, and future ...
4-1BBL, a member of the TNF superfamily, is expressed in B cells, dendritic cells, activated T cells and macrophages. 4-1BBL binds to its receptor 4-1BB, and provides a co-stimulatory signal for T cell activation and expansion. The human 4-1BBL gene codes for a 254 amino acid type...
signals:aprimarysignal initiated by the engagement ofaTCRwitha MHC/peptidecomplex anda secondarysignal mediated throughcostimulatory molecules expressed onthesurfaceoftheTcell.It is currently believedthat signals are usually transduced through the
Crystal Mackall and colleagues report that antigen-independent signaling of chimeric antigen receptors (CARs) causes T cell exhaustion and reduced therapeutic efficacy of CAR T cells that can be overcome by incorporating the 4-1BB costimulatory domain in