4-1BB signaling beyond T cells. Cell Mol Immunol. 2011;8:281–4. CentralVinay, D.S. and B.S. Kwon, 4-1BB signaling beyond T cells. Cell Mol Immunol, 2011. 8(4): p. 281-4.Dass S Vinay,Byoung S Kwon. 4-1BB signaling beyond T cells[J]. 2011.doi:10.1038/cmi.2010.82...
由于4-1BB在多种免疫细胞中表达,包括T细胞、B细胞、NK细胞、嗜酸性粒细胞和DCs等,所以,近年来,基于4-1BB/4-1BBL的共刺激信号在各种免疫细胞培养方向的广泛应用成为行业关注的要点。 This illustration depicts the cascade of events involved in 4-1BB signaling and its effects on T-cell function. xp Mol...
4）此外，树突状细胞（DCs）在4-1BB介导的抗肿瘤免疫中也起着关键作用。体内DCs的耗竭能降低CTL的刺激水平，进一步削弱4-1BB mAbs的作用。总的来说，4-1BB抗体通过4-1BB信号激活各种免疫细胞，调节T活性、诱导细胞因子、防止活化诱导的细胞死亡（AICD）和CTL活性升高。根据市场需求和研究现状，构建4-1BB过表达...
Cheuk AT, Mufti GJ, Guinn BA. Role of 4-1BB:4-1BB ligand in cancer immunotherapy. Cancer Gene Ther. 2004 Mar;11(3):215-26. Vinay DS, Kwon BS. 4-1BB signaling beyond T cells. Cell Mol Immunol. 2011 Jul;8(4):281-4. Bartkowiak T, Curran MA. 4-1BB Agonists: Multi-Potent Po...
5.Benjamin I Philipson et al,4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling,Sci Signal . 2020 Mar 31;13(625):eaay8248. 6.Chester C, Sanmamed MF, Wang J, Melero I.Immunotherapy targeting 4-1BB: mechanistic rationale, clinical results, and future ...
4-1BB is expressed on the surface of activated T cells, NK cells, NKT cells and so on[2]. It provides co-stimulatory signals and activates cytotoxic effects of CD8+ T cells and facilitates the development memor...
Vinay DS, Kwon BS. 4-1BB signaling beyond T cells. Cell Mol Immunol. 2011 Jul;8(4):281-4. Bartkowiak T, Curran MA. 4-1BB Agonists: Multi-Potent Potentiators of Tumor Immunity. Front Oncol. 2015 Jun 8;5:117. Chester C, Sanmamed MF, Wang J, Melero I. Immunotherapy targeting 4-...
Since 4-1BB has a distinct signaling path- way from CD28 (Saoulli et al., 1998), and 4-1BB has a later role in sustaining the immune response (Cannon et al., 2001), it is believed that 4-1BB functions independently of CD28. In one model, however, 4-1BB stimulation enhances a ...
“c-IAP ubiquitin protein ligase activity is required for 4-1BB signaling and CD8(+) memory T-cell survival.” Eur J Immunol 45(9): 2672-2682 in vivo 4-1BB stimulation Guillerey, C., et al. (2015). “Immunosurveillance and therapy of multiple myeloma are CD226 dependent.” J Clin ...
drug-resistant B-lineage acute lymphoblastic leukemia (ALL), we transduced T lymphocytes with anti-CD19 chimeric receptors, consisting of an anti-CD19 single-chain variable domain (reactive with most ALL cases), the hinge and transmembrane domains of CD8alpha, and the signaling domain of CD3zeta...