The present study will examine the effects of 12 weeks of treadmill exercise on spatial learning and memory using an eight-arm radial maze in six-month-old 3×Tg-AD mice. Then, the potential mechanisms involved are investigated. The hippocampus and prefrontal cortex are known to be critical ...
Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status. Germline mutations in the FH gene encoding the Krebs cycle enzyme fumarate hydratase predispose to hereditary leiomyomatosis and renal cell cancer (HLRCC) ... C Bardella,...