S-SCAM/MAGI-2 gene duplication is associated with schizophrenia (SCZ). S-SCAM overexpression in the forebrain induces SCZ-like phenotypes in a transgenic (Tg) mouse model. Interestingly, S-SCAM Tg mice show male-specific impairments in synaptic plasticit
1b). In the light-dark box test, Top3β-KO mice entered the light box significantly fewer times than did WT mice (Fig. 1c). Together, these results indicate that Top3β-KO mice have greater generalized anxiety level, a phenotype prevalent in schizophrenia patients20,21....
W week; g qRT-PCR detection of miR-188-3p expression level in tumor lesions dissected from xenograft nude mice, *p < 0.001 compared with control; h western-blot detection of variation of TMED3 in tumor lesions dissected. Shown was representative figure picked out of three times of ...
Cardiomyocyte-specific Tg-FLAG-PPARα (α-myosin heavy chain promoter) mice were a kind gift from Dr. D. Kelly. Male C57BL/6J ob/ob mice and male C57BL/6J wild-type mice were purchased from Jackson Labs at 5-6 weeks of age. For diet-induced obesity, male 5 to 6-week-old animals...
1E), and injected them into nude mice subcutaneously to establish the xenograft model. miR-550a-3-5p overexpression, both in HPV-positive and HPV-negative OSCC cells, led to a decrease in tumor volume and tumor weight with respect to the vector control group (Fig. 3a-c). HE staining ...
Primer pheromones are exemplified by their effects on the onset of puberty, the length of estrous cycles in females, the success or failure of pregnancy, and shifts in hormone levels in mice [6]. Male pheromones have a direct impact on female sexual desire, menstrual cycles and ovulation in ...
aEighteen tumor-bearing nude mice were randomly divided into 6 groups(n=3). Biodistribution in vivo and SPECT imaging in vitro in the nude mice were observed in different times after intravenous injection 0.74 MBq (0.1mL) of the molecular probe,and 99Tcm-MDP imaging in different times were ...
We found that IFNβ directly acts on T cells to enhance Treg cell induction both in vivo in mice and in vitro in mouse and human cells, as well as to prolong allograft survival (mouse). Guided by a mechanistic computational model, we discovered that IFNβ achieves its Treg cell-enhancing...
Each experiment was triplicated independently and repeated three times. After normalizing the transfection efficiency, the results were expressed as folds compared to control. Tumor xenografts in nude mice BALB/C-nu/nu nude mice were purchased from the National Resource Center for Rodent Laboratory ...
Although defects in intracellular calcium homeostasis are known to play a role in the pathogenesis of Parkinson’s disease (PD), the underlying molecular mechanisms remain unclear. Here, we show that loss of PTEN-induced kinase 1 (PINK1) and Parkin leads