Here, 3xTg-AD mice demonstrate that the sensorial-discriminative threshold to a noxious cold stimulus, as measured by the latency of tail-flicking, was preserved at early and advances stages of disease (7 and 11 month-old, respectively) as compared to age-matched (adulthood and middle aged, ...
rCV01 elicited robust Th2-polarized Aβ-specific antibodies without autoimmune T cell responses in 3 × Tg-AD mice. The long-lasting anti-Aβ42 antibodies were associated with markedly reduced AD-like pathology, enhanced synaptic function, and improved cognitive performance in aged 3 × Tg-AD ...
Cinnamaldehyde prevents intergenerational effect of paternal depression in mice via regulating GR/miR-190b/BDNF pathway Zhi-ying Gao Tian-yu Chen Ling-dong Kong Acta Pharmacologica Sinica (2022)Download PDF Sections Figures References Abstract Introduction Results Discussion Materials and Methods Additio...
1b). In the light-dark box test, Top3β-KO mice entered the light box significantly fewer times than did WT mice (Fig. 1c). Together, these results indicate that Top3β-KO mice have greater generalized anxiety level, a phenotype prevalent in schizophrenia patients20,21....
近日,THE(Times Higher Education)发布了2024年年轻大学排名,揭晓了建校50年及以下的最佳大学。 01 THE排名 泰晤士高等教育年轻大学排名采用与世界大学排名相同的方法论,以衡量科研密集型大学的所有核心任务:教学、研究、知识转移和国际视野。 具体排名...
Genetic OGG1 deficiency increases the risk of AD, whose pathogenesis is amplified by NLRP3 inflammasome activation (Heneka et al., 2015; Heneka et al., 2013), and high amounts of 8-oxoG-containing DNA and reduced OGG1 activity are detected (Mao et al., 2007). In mice, OGG1 deficiency...
通过鉴定eslec作为嗜酸性粒细胞特异性标志物,作者建立了Tg(eslec:eGFP)报告基因系,它特异性地标记了从早期到成熟期的嗜酸性粒细胞。对eslec+细胞的时空分析证明了它们从早期到成熟期的器官分布。通过单细胞RNA-Seq分析,作者破译了嗜酸性粒细胞从祖细胞到成熟嗜酸性粒细胞的过程。通过进一步的遗传分析,作者证明了Ceb...
Mice were killed using isoflurane after 8 times taking notes of tumor volume, and tumors were collected for weights measuring and further examination. For 4NQO-indued OSCC model of transgenic mice, a total of sixteen 7-week-old female Rosa26-E6-E7 constitutive knock-in C57BL/6 mice (Cyagen...
甘油三酯(TG)和富含甘油三酯的脂蛋白(TRL)水平升高作为我国人群最常见的血脂异常表型之一,是近年来证据较多且备受关注的他汀类药物治疗后心血管剩余风险的重要组成部分。既往观点认为,ω-3脂肪酸可通过降低TG和TRL水平以改善患者心血管事件发生风险...
Studies have found that in the hippocampus of 3XTg-AD mice, the decrease in phosphorylation of AKT in the insulin signaling pathway leads to a decrease in GLUT3 translocation. This reduction in GLUT3 on the cell membrane may impair neurons’ ability to take up glucose42. Existing evidence ...