Seven﹚eek﹐ld female 3xTg (n = 19) and ageand gender﹎atched wild‐type (n = 19) mice were corneally kindled with the 6 Hz electrical stimulations.4 Corneal kindling is a model of repeated induced seizures, where identical electric stimuli applied to the eyes, give rise to a ...
3xTg Alzheimer's disease mice are more susceptible to induced seizures: Development of new models and analysis methods/behavioral models doi:10.1002/alz.044096Alzheimer's & Dementia: The Journal of the Alzheimer's AssociationVyver, Maxime VandeDe Bundel, DimitriNagels, GuyEngelborghs...
Combinational vaccine improves motor function, recognition, and memory ability in 3xTg mice of the premorbid group Fig. 3: Impact of vaccines on behavioral and cognitive aspects in premorbid 3xTg mice. Full size image Dual vaccine mitigates Aβ and pTau pathology and consequently relieves the be...
Comment on: Extra‐virgin olive oil ameliorates cognition and neuropathology of the 3xTg mice: role of autophagy Lauretti E, Iuliano L, Pratico D (2017) Extra-virgin olive oil ameliorates cognition and neuropathology of the 3xTg mice: role of autophagy. Ann Clin Transl Neurol 4: 564-574....
www.nature.com/scientificreports OPEN Age-dependent inverse correlations in CSF and plasma amyloid-β(1–42) concentrations prior to amyloid received: 06 July 2015 accepted: 23 December 2015 Published: 02 February 2016 plaque deposition in the brain of 3xTg-AD mice Soo Min Cho1,2,*, ...
Billings LM, Oddo S, Green KN, McGaugh JL, LaFerla FM. Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron. 2005 Mar 3;45(5):675-88. Stover KR, Campbell MA, Van Winssen CM, Brown RE. Early detection of cognitive defi...
·神经系统疾病的基础研究·３ｘＴｇ－拟ＡＤ小鼠脑内七种时钟基因启动子区甲基化分析 包训杰１，３ 蔡彦宁２，３ 祝艳秋１，３ 杨翠翠１，３ 李 林１，３ 张 兰 １，３倡 （１．首都医科大学宣武医院药物研究室，北京１０００５３；２．首都医科大学宣武医院神经生物学研究室，北京１０００５３；...
The female 3xTg mice failed to exhibit any deficits in spatial learning and memory as measured in the Morris water maze, indicating that when backcrossed to the C57Bl/6 strain, the 3xTg mice lost the behavioral phenotype that was present in the original 3xTg mouse maintained on a hybrid ...
We also evaluated signs of mitochondrial dysfunction and found that Zn2+ supplementation prevents the age-dependent respiratory deficits we observed in untreated 3xTg-AD mice. Finally, we found that Zn2+ supplementation greatly increases the levels of brain-derived neurotrophic factor (BDNF) of ...
Comment on: Extra‐virgin olive oil ameliorates cognition and neuropathology of the 3xTg mice: role of autophagy Lauretti E, Iuliano L, Pratico D (2017) Extra-virgin olive oil ameliorates cognition and neuropathology of the 3xTg mice: role of autophagy. Ann Clin Transl Neurol 4: 564-574....