Billings LM, Oddo S, Green KN, McGaugh JL, LaFerla FM. Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron. 2005 Mar 3;45(5):675-88.Stover KR, Campbell MA, Van Winssen CM, Brown RE. Early detection of cognitive defici...
Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron. 2005 Mar 3;45(5):675-88. Stover KR, Campbell MA, Van Winssen CM, Brown RE. Early detection of cognitive deficits in the 3xTg-AD mouse model of Alzheimer's disease. Be...
Billings LM, Oddo S, Green KN, McGaugh JL, LaFerla FM. Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron. 2005 Mar 3;45(5):675-88. Stover KR, Campbell MA, Van Winssen CM, Brown RE. Early detection of cognitive defi...
www.nature.com/scientificreports OPEN Age-dependent inverse correlations in CSF and plasma amyloid-β(1–42) concentrations prior to amyloid received: 06 July 2015 accepted: 23 December 2015 Published: 02 February 2016 plaque deposition in the brain of 3xTg-AD mice Soo Min Cho1,2,*, ...
3xTg-AD miceAnimal modelsAlzheimer's disease (AD) is a devastating disease, and the most common form of dementia to afflict the elderly population. The disease causes a slow but progressive neurodegeneration, leading to...doi:10.1007/978-1-60761-898-0_24Michael Sy...
3xTg-AD小鼠|AD模型 3xTg-AD (B6;129) ,俗称“三转鼠” 别名:3xTg-AD, The LaFerla mouse 物种:小鼠 基因:APP,PSEN1,MAPT 突变:APP K670_M671delinsNL(瑞典型),MAPT P301L,PSEN1 M146V 编辑类型:APP - 转基因;PSEN1 - 转基因;MAPT - 转基因...
2 号染色体上插入的转基因造成 3 bp 缺失。 参考文献: Belfiore R; Rodin A; Ferreira E; Velazquez R; Branca C; Caccamo A; Oddo S. 2019. Temporal and regional progression of Alzheimer's disease-like pathology in 3xTg-AD mice. Aging Cell 18(1):e12873 PubMed: 30488653 MGI: J:273259 ...
2 号染色体上插入的转基因造成 3 bp 缺失。 参考文献:Belfiore R; Rodin A; Ferreira E; Velazquez R; Branca C; Caccamo A; Oddo S. 2019. Temporal and regional progression of Alzheimer's disease-like pathology in 3xTg-AD mice. Aging Cell 18(1):e12873 PubMed: 30488653 MGI: J:273259...
Finally, we found that Zn2+ supplementation greatly increases the levels of brain-derived neurotrophic factor (BDNF) of treated 3xTg-AD mice. In summary, our data support the idea that controlling the brain Zn2 þ homeostasis may be beneficial in the treatment of AD. Cell Death and Disease...
After almost 15years from their generation, 3xTg‐AD mice are still one of the most used transgenic models of AD. Converging evidence indicates that the phenotype of 3xTg‐AD mice has shifted over the years and contradicting reports about onset of pathology or cognitive deficits are apparent in...