该研究是张进课题组在2021年7月31日Protein & Cell杂志上发表的题为“LIN28 Coordinately Promotes Nucleolar/Ribosomal Functions and Represses the 2C-like Transcriptional Program in Pluripotent Stem Cells”的研究论文的进一步拓展。...
[9].Zhen Sun, Jin Zhang. et al. LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells. Protein & Cell (2021)
A minority of mouse embryonic stem cells (ESCs) display totipotent features resembling 2-cell stage embryos and are known as 2-cell-like (2C-like) cells. However, how ESCs transit into this 2C-like state remains largely unknown. Here, we report that the overexpression of n...
In vitro culture of isolated primary hepatocytes and stem cell-derived hepatocyte-like cells for liver regeneration 胚胎干细胞原代肝细胞体外培养功能分离肝再生microRNA间充质干细胞肝脏疾病Various liver diseases result in terminal hepatic failure, and liver transplantation, ... C Hu,L Li - 《蛋白质与...
Mouse embryonic stem cells (ESCs) sporadically transit into an early embryonic-like state characterized by the expression of 2-cell (2C) stage-restricted transcripts. Here, we identify a maternal factor—negative elongation factor A (NELFA)—whose heterogeneous expression in mouse ESCs is coupled ...
(C) RNA-seq expression of transcripts per kilobase million (TPM) of 2C-like cell markers in Setdb1-CKO cells under both conditions (3 independent RNA-seq experiments; error bar, SD; ∗p < 0.05) (D) Volcano plots showing the fold changes transcriptomes of Setdb1-CKO cells in SL/2...
Totipotent cells have the ability to generate embryonic and extra-embryonic tissues. Interestingly, a rare population of cells with totipotent-like potential, known as 2 cell (2C)-like cells, has been identified within ESC cultures. They arise from ESC a
Cardiomyocyte regeneration is limited in adults. The adipose tissue-derived stromal vascular fraction (Ad-SVF) contains pluripotent stem cells that rarely transdifferentiate into spontaneously beating cardiomyocyte-like cells (beating CMs). However, the
The density of tumor-infiltrating CD8(+) T cells in PCa is associated with a better prognosis. It remains unclear how PLC-L2 affects the TIL and PCa. A human tissue microarray (TMA) and PCa patients from the Cancer Genome Atlas were used to address the correlations between PLC-L2 and ...
2021年7月31日张进课题组在Protein & Cell杂志上发表的题为LIN28 Coordinately Promotes Nucleolar/Ribosomal Functions and Represses the 2C-like Transcriptional Program in Pluripotent Stem Cells的研究论文(Protein & Cell丨张进团队揭示核仁定位的RNA结合蛋白LIN28调控小鼠胚胎干细胞多能性状态与二细胞样状态转变的...