张进团队揭示细胞周期与胚胎干细胞2C状态进入与退出的关联 2012年Todd S. Macfarlan等科学家发现,在体外培养的小鼠ESCs具有异质性,有约1%的细胞在基因表达与染色质调控等方面与2-细胞期胚胎相似,这群细胞具有更高的发育潜能,它们既能分化成胚胎组...
2012年 Todd S. Macfarlan 等科学家发现,在体外培养的小鼠胚胎干细胞(ESCs)具有异质性,有约1%的细胞在基因表达与染色质调控等方面与2-细胞期胚胎相似,这群细胞具有更高的发育潜能,它们既能分化成胚胎组织,又能够分化成胚外组织,因而被称作...
2012年 Todd S. Macfarlan 等科学家发现,在体外培养的小鼠胚胎干细胞(ESCs) 具有异质性,有约1%的细胞在基因表达与染色质调控等方面与2-细胞期胚胎相似,这群细胞具有更高的发育潜能,它们既能分化成胚胎组织,又能够分化成胚外组织,因而被称作2-细胞样细胞(2-Cell Like Cell,2CLC) 【1】 。然而,2CLC状态是极...
).值得注意的是,小鼠胚胎干细胞中含有少量的亚细胞群(小于1%),其基因表达模式类似2-细胞期胚胎,这一类细胞称为2-细胞期胚胎样细胞(2-cell embryo like cell, 2C-like cell).在适当的体外培养条件下,小鼠胚胎干细胞和诱导多能性干细胞(induced pluripotent stem cell, iPSC)中均会自发产生少量的2C-like细胞....
Mouse embryonic stem cells (ESCs) sporadically transit into an early embryonic-like state characterized by the expression of 2-cell (2C) stage-restricted transcripts. Here, we identify a maternal factor—negative elongation factor A (NELFA)—whose heterogeneous expression in mouse ESCs is coupled ...
2-cell-like programnucleolar integrityNCL/TRIM28 complexLIN28 is an RNA binding protein with important roles in early embryo development, stem cell differentiation/reprogramming, tumorigenesis and metabolism. Previous studies have focused mainly on its role in the cytosol where it interacts with Let-7...
克隆类型 polyclonal 交叉反应 Human 产品类型 一抗 别 名 Natural killer cell group 2C; natural killer cell protein group 2-C; NKG2-C type II integral membrane protein; NKG2-C-activating NK receptor; NK cell receptor C; CD159 antigen-like family member C; CD159c; KLRC2 protein; NKG2C_...
(C) RNA-seq expression of transcripts per kilobase million (TPM) of 2C-like cell markers in Setdb1-CKO cells under both conditions (3 independent RNA-seq experiments; error bar, SD; ∗p < 0.05) (D) Volcano plots showing the fold changes transcriptomes of Setdb1-CKO cells in SL/2...
Totipotent cells have the ability to generate embryonic and extra-embryonic tissues. Interestingly, a rare population of cells with totipotent-like potential, known as 2 cell (2C)-like cells, has been identified within ESC cultures. They arise from ESC a
鸡胰岛素样生长因子结合蛋白1(IGFBP1)ELISA试剂盒ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) 鸡Ⅰ型胶原α2(COL1α2)ELISA试剂盒ELISA Kit for Collagen Type I Alpha 2 (COL1a2) 鸡60kD热休克蛋白(HSPD1)ELISA试剂盒ELISA Kit for Heat Shock 60kD Protein 1, Chaperonin (HS...