多种抑制rRNA生成的方法可以诱发核仁应激 (nucleolar stress) ,导致核仁周边异染色质的变化从而解除对Dux等2C基因的抑制,最终促进ES细胞向2C-like细胞的命运转变。 该研究是张进课题组在2021年7月31日Protein & Cell杂志上发表的题为...
[9].Zhen Sun, Jin Zhang. et al. LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells. Protein & Cell (2021)
A minority of mouse embryonic stem cells (ESCs) display totipotent features resembling 2-cell stage embryos and are known as 2-cell-like (2C-like) cells. However, how ESCs transit into this 2C-like state remains largely unknown. Here, we report that the overexpression of n...
Mouse embryonic stem cells (ESCs) sporadically transit into an early embryonic-like state characterized by the expression of 2-cell (2C) stage-restricted transcripts. Here, we identify a maternal factor—negative elongation factor A (NELFA)—whose heterogeneous expression in mouse ESCs is coupled ...
Inter- estingly, a rare population of cells with totipotent-like potential, known as 2 cell (2C)-like cells, has been identified within ESC cultures. They arise from ESC and display similar fea- tures to those found in the 2C embryo. However, the molecular determinants of 2C-like ...
Totipotent cells have the ability to generate embryonic and extra-embryonic tissues. Interestingly, a rare population of cells with totipotent-like potential, known as 2 cell (2C)-like cells, has been identified within ESC cultures. They arise from ESC a
This “ground state” Setdb1-null population undergoes rapid cell death by activating Ripk3 and, subsequently, RIPK1/RIPK3-dependent necroptosis. These results reveal the essential role of Setdb1 between totipotency and pluripotency transition. Graphical Abstract Download: Download high-res image (...
cell with intracellular calcium ion oscillation. Arrow shows an elongated cell that is changing from the round form and beginning to beat spontaneously. (g) Maximal rate of shortening (dL/dt) and relaxing (–dL/dt) in each cycle of contractions of a representative isolated SVF beating cell on...
PPTC7, CT (PPTC7, TAPP2C, Protein phosphatase PTC7 homolog, T-cell activation protein phosphatase 2C, T-cell activation protein phosphatase 2C-like) 供应商 MyBioSource 产品货号 MBS649045 产品报价 ￥询价/0.2mL ￥询价/5x0.2mL ￥询价/其它规格 ...
这两项研究与张进课题组近期关于胚胎代谢(Nat Metab | 张进/胡泽平合作揭示小鼠着床前胚胎发育的代谢重塑与代谢调控)(Nature Metabolism, 2021)和细胞周期对2CLC的影响(Stem Cell Report, 2021) 的研究共同探索了传统被认为具有持家基因(housekeeping gene)功能的核仁、代谢等,在早期胚胎发育和细胞命运转变中的特异...