(totipotent).值得注意的是,小鼠胚胎干细胞中含有少量的亚细胞群(小于1%),其基因表达模式类似2-细胞期胚胎,这一类细胞称为2-细胞期胚胎样细胞(2-cell embryo like cell, 2C-like cell).在适当的体外培养条件下,小鼠胚胎干细胞和诱导多能性干细胞(induced pluripotent stem cell, iPSC)中均会自发产生少量的2C-...
这两项研究与张进课题组近期关于胚胎代谢(Nat Metab | 张进/胡泽平合作揭示小鼠着床前胚胎发育的代谢重塑与代谢调控)(Nature Metabolism, 2021)和细胞周期对2CLC的影响(Stem Cell Report, 2021) 的研究共同探索了传统被认为具有持家基因(housekeeping gene)功能的核仁、代谢等,在早期胚胎发育和细胞命运转变中的特异作...
(totipotent).值得注意的是,小鼠胚胎干细胞中含有少量的亚细胞群(小于1%),其基因表达模式类似2-细胞期胚胎,这一类细胞称为2-细胞期胚胎样细胞(2-cell embryo like cell, 2C-like cell).在适当的体外培养条件下,小鼠胚胎干细胞和诱导多能性干细胞(induced pluripotent stem cell, iPSC)中均会自发产生少量的2C-...
[9].Zhen Sun, Jin Zhang. et al. LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells. Protein & Cell (2021)
Mouse embryonic stem cells (ESCs) sporadically transit into an early embryonic-like state characterized by the expression of 2-cell (2C) stage-restricted transcripts. Here, we identify a maternal factor—negative elongation factor A (NELFA)—whose heterogeneous expression in mouse ESCs is coupled ...
cell with intracellular calcium ion oscillation. Arrow shows an elongated cell that is changing from the round form and beginning to beat spontaneously. (g) Maximal rate of shortening (dL/dt) and relaxing (–dL/dt) in each cycle of contractions of a representative isolated SVF beating cell on...
T Cell InfiltrateCD8(+) T CellsPLC-L2, whose related members of its family facilitate in the differentiation of T cells, is a potential epigenetic marker for PCa. The density of tumor-infiltrating CD8(+) T cells in PCa is associated with a better prognosis. It remains unclear how PLC-L2...
摘要: The Cdc2-like kinases (CLKs) regulate RNA splicing and have been shown to suppress cell growth. Knockdown of CLK2 was found to block glioma stem-like cell (GSC) growth关键词:CLK2 FGFR PI3K/mTOR glioblastoma glioma stem cells survival ...
展开 关键词: Humans Saccharomyces cerevisiae Escherichia coli Saccharomyces cerevisiae Proteins Pregnancy Proteins Recombinant Proteins Nucleocytoplasmic Transport Proteins Cell Cycle Proteins Ligands Crystallography, X-Ray DOI: 10.1371/journal.pone.0080947 被引量: 18 年份...
Mesenchymal stem cell‐derived CCN2 promotes the proliferation, migration and invasion of human tongue squamous cell carcinoma cells Recent studies have demonstrated that mesenchymal stem cells (MSC) exhibit a tropism to tumors and form the tumor stroma. In addition, we found that MSC ca... YL ...