15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) 是一种环戊烯酮前列腺素和 PGD2 的代谢产物。15-Deoxy-Δ-12,14-prostaglandin J2 是一种选择性的PPARγ(EC50为 2 µM) 和共价的 15-Deoxy-Δ12,14-Prostaglandin J2-d9Chemical Structure *Please selectQuantitybefore adding items. 上海金畔生物科技...
(PG)D2 and 15-deoxy-D12,14-PGJ2, but not PGE2, mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases F Zhu1, P Wang1, A Kontrogianni-Konstantopoulos2 and K Konstantopoulos*,1 Excessive mechanical loading of cartilage producing hydrostatic ...
15-Deoxy-Δ12,14-prostaglandin J2 (15dPGJ2), which is a ligand for peroxisome proliferatoractivated receptor γ (PPARγ), induced apoptosis of several human tumors including gastric, lung, colon, prostate and breast. However, the role of PPARγ signals in other types of cancer cells such as...
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Therefore, our study showed the 15d-PGJ2to potentially be an interesting approach for RCC treatment. 展开 关键词: 15-deoxy-Δ12,14prostaglandin J2 PPARγ Renal cell carcinoma Apoptosis JNK MAPK Akt DOI: 10.7150/ijms.4455 被引量: 18
The endogenous PPARgamma ligand, 15-deoxy-Delta12,14-PGJ2 (15d-PGJ2), and the synthetic ligand, ciglitazone, have anti-inflammatory properties in endothelial cells. In addition to PPARgamma-dependent effects on the anti-inflammatory process, it has been proposed that PPARgamma ligands may also...