Here, we use positron emission tomography (PET) to assess the density of synapses with synaptic vesicle glycoprotein 2A (SV2A) in autistic adults usingC-UCB-J. Twelve autistic (mean (SD)age 25 (4)years; six males), and twenty demographically matched non-autistic individuals (26 (3)years;...
We propose that DLB is associated instead with severe synaptic loss, and we test this hypothesis in vivo using positron emission tomography (PET) imaging of C-UCB-J, a ligand for presynaptic vesicle protein 2A (SV2A), a vesicle membrane protein ubiquitously expressed in synapses. Methods We ...
Methods: 11C-PIB PET was performed to determine brain amyloid status. A structural T1-weighted MR was acquired to exclude structural abnormalities and for PET co-registration and analysis. 11C-UCB-J binding to SV2A was measured in 38 AD (24 dementia, 14 mild cognitive impairment) and 19 ...
In fact, we have reported that 11C-UCB-J PET in the pregnant non-human primate demonstrated progressive increases in the fetal brain that can be interpreted as synaptogenesis during brain development. We, therefore, evaluated 11CUCBJ PET imaging in rats to provide insights into synaptogenesis ...
EJNMMI Research (2022) 12:3 https://doi.org/10.1186/s13550-021-00874-8 ORIGINAL RESEARCH Open Access Validation and test–retest repeatability performance of parametric methods for [11C] UCB‑J PET Hayel Tuncel1*, Ronald Boellaard1, Emma M. Coomans1, Marijke den ...
11C-UCB-J PET study]]>PETresting-state network (RSN)fMRImultimodal neuroimaging11C-UCB-JSV2AICAIntroduction: Resting-state network (RSN) connectivity is a widely used measure of the brains functional organization in health and disease; however, little is known regarding...
Conclusion : In vivo, PET using C-UCB-J does not support a cortical decrease of synaptic density with aging, whereas subcortically a small effect with aging in the caudate nucleus was observed. In addition, no association between synaptic density and sex was detected, which allows pooling of ...
A subset of 13 participants (Table 1) were selected who had completed cognitive testing, structural MR imaging, and PET imaging with the following: [11C]PiB centiloid (CL) for amyloid +/- status, [18F]MK-6240 SUVR for tau +/- status, [11C]UCB-J DVR for regional synaptic ...
Simplified Quantification of 11C-UCB-J PET Evaluated in a Large Human Cohort.doi:10.2967/JNUMED.120.243949Mika NaganawaJean Dominique GallezotSjoerd J. FinnemaDavid MatuskeyAdam MeccaNabeel B. NabulsiDavid LabareeJim RopchanRobert T. Malison
However, initial attempts using PET imaging to associate synaptic density with cognitive performance have been hindered by the use of limited cognitive measures. In this study we examined the relationship between synaptic density and cognitive performance in early AD using [C]UCB-J PET and an ...