11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adultsThe neural bases of autism are poorly understood at the molecular level, but evidence from animal models, genetics, post-mortem studies, and single-gene disorders implicate synaptopathology. Here, we use positron ...
C-UCB-J binding was quantified using non-displaceable binding potential (BPND) determined from dynamic imaging. Changes in C-UCB-J binding were correlated with MRI regional brain volume, C-PiB uptake and F-AV-1451 binding. Results Compared to controls, both patients had decreased C-UCB-J ...
Methods: 11C-PIB PET was performed to determine brain amyloid status. A structural T1-weighted MR was acquired to exclude structural abnormalities and for PET co-registration and analysis. 11C-UCB-J binding to SV2A was measured in 38 AD (24 dementia, 14 mild cognitive impairment) and 19 ...
Here, we propose a method for imaging SV2A, a presynaptic vesicle protein, in the human SC with 11C-UCB-J PET/CT, by using the CT image to define the location of the SC. We also assess the specificity of 11C-UCB-J binding in the cervical SC through an occupancy analysis conducted ...
EJNMMI Research (2022) 12:3 https://doi.org/10.1186/s13550-021-00874-8 ORIGINAL RESEARCH Open Access Validation and test–retest repeatability performance of parametric methods for [11C] UCB‑J PET Hayel Tuncel1*, Ronald Boellaard1, Emma M. Coomans1, Marijke den ...
doi:10.1002/alz.037789John Wiley & Sons, LtdAlzheimer's & Dementia
11C-UCB-JSV2AICAIntroduction: Resting-state network (RSN) connectivity is a widely used measure of the brains functional organization in health and disease; however, little is known regarding the underlying neurophysiology of RSNs. The aim of the current study was to ...
P-048 - A new phenylstannyl precursor for synthesizing [11C]UCB-Jdoi:10.1016/j.nucmedbio.2023.108520Wakana MoriNobuki NengakiHideki IshiiKatsushi KumataMasayuki FujinagaMing-Rong ZhangElsevier Inc.Nuclear Medicine and Biology
Synaptic density in healthy human aging is not influenced by age or sex: a 11C-UCB-J PET study(11)C-UCB-JPETSV2ASynaptic densityagingRationale : C-UCB-J binds to synaptic vesicle glycoprotein 2A, a protein ubiquitously expressed in presynaptic nerve terminals, and can therefore serve as in...
Simplified Quantification of 11C-UCB-J PET Evaluated in a Large Human Cohort.doi:10.2967/JNUMED.120.243949Mika NaganawaJean Dominique GallezotSjoerd J. FinnemaDavid MatuskeyAdam MeccaNabeel B. NabulsiDavid LabareeJim RopchanRobert T. Malison