Here, we use positron emission tomography (PET) to assess the density of synapses with synaptic vesicle glycoprotein 2A (SV2A) in autistic adults usingC-UCB-J. Twelve autistic (mean (SD)age 25 (4)years; six males), and twenty demographically matched non-autistic individuals (26 (3)years;...
The DLB subjects also underwent PET imaging of amyloid (C-PiB) and tau (F-AV-1451). C-UCB-J binding was quantified using non-displaceable binding potential (BPND) determined from dynamic imaging. Changes in C-UCB-J binding were correlated with MRI regional brain volume, C-PiB uptake and...
In fact, we have reported that 11C-UCB-J PET in the pregnant non-human primate demonstrated progressive increases in the fetal brain that can be interpreted as synaptogenesis during brain development. We, therefore, evaluated 11CUCBJ PET imaging in rats to provide insights into synaptogenesis ...
Methods: 11C-PIB PET was performed to determine brain amyloid status. A structural T1-weighted MR was acquired to exclude structural abnormalities and for PET co-registration and analysis. 11C-UCB-J binding to SV2A was measured in 38 AD (24 dementia, 14 mild cognitive impairment) and 19 ...
EJNMMI Research (2022) 12:3 https://doi.org/10.1186/s13550-021-00874-8 ORIGINAL RESEARCH Open Access Validation and test–retest repeatability performance of parametric methods for [11C] UCB‑J PET Hayel Tuncel1*, Ronald Boellaard1, Emma M. Coomans1, Marijke den ...
11C-UCB-JSV2AICAIntroduction: Resting-state network (RSN) connectivity is a widely used measure of the brains functional organization in health and disease; however, little is known regarding the underlying neurophysiology of RSNs. The aim of the current study was to ...
[11C]UCB-J PETsynapseneuropsychologyBackground: Patients with Parkinson's disease (PD) often develop dementia, but the underlying substrate is incompletely understood. Generalized synaptic degeneration may contribute to dysfunction and cognitive decline in Lewy body dementias, but in vivo evidence is ...
A subset of 13 participants (Table 1) were selected who had completed cognitive testing, structural MR imaging, and PET imaging with the following: [11C]PiB centiloid (CL) for amyloid +/- status, [18F]MK-6240 SUVR for tau +/- status, [11C]UCB-J DVR for regional synaptic ...
Simplified Quantification of 11C-UCB-J PET Evaluated in a Large Human Cohort.doi:10.2967/JNUMED.120.243949Mika NaganawaJean Dominique GallezotSjoerd J. FinnemaDavid MatuskeyAdam MeccaNabeel B. NabulsiDavid LabareeJim RopchanRobert T. Malison
In this study, we examined in vivothe association between fibrillar Aβ deposition and synaptic density in early AD using [C]PiB and [C]UCB-J PET. We hypothesized that global Aβ deposition would be more strongly inversely associated with hippocampal synaptic density in participants with amnestic...