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A 'metastasis-prone' signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics. Clin Exp Metastasis 2010; 27:83–90. Article CAS Google Scholar Kaneda H, Arao T, Tanaka K, et al. FOXQ1 is overexpressed in colorectal ...
(D) NICD expression in zebrafish embryos treated with 7α-25-OHC (from 1-cell stage to 36 hpf) or MG132 (from 26 to 36 hpf). Right panel shows the quantification analysis. (E) MS analysis of Notch1-interacting proteins in control or 7α-25-OHC-treated AGM cells. Mouse E10.5 AGM ...
2022年3月,由中国科学院和深圳华大生命科学研究院牵头的体细胞诱导培养人类全能干细胞研究在Nature上发文“Rolling back human pluripotent stem cells to an eight-cell embryo-like stage”。在这项研究中,科研团队开发了一种非转基因、快速且可控的方法,从人类多能干细胞中诱导产生8C样细胞(8C-like cells,8CLC...
animmunotherapyapproach was able to induce large shifts and diversification in TCR repertoires, suggesting that dual targeting of PD-1 and CTL-4 may prove efficacious, with anti-CTLA-4 antibodies most effective in the T cell priming stage and the anti-PD-1 targeting T cell expansion and ...
Stage-specific roles of microbial dysbiosis and metabolic disorders in rheumatoid arthritis 2022-08-19, doi: 10.1136/ard-2022-222871 慢性肾病患儿的炎症表型与肠道菌群紊乱及代谢产物失衡有关 Journal of the American Society of Nephrology : JASN——[14.978] ...
G0 phase (resting stage): the cell is at rest and has not started to divide. This can last for a few hours to a few years, depending on the circumstances (reproductive cells have a very short resting phase whereas plant seeds have been known to germinate many years after they have been...
Our results shows that CTC is potentially an intermediate stage between primary and tumor, is considered as precursor of tumor metastasis. Studies related to hepatocellular carcinoma have shown that CTCs enter the bloodstream from primary tumors and metastatic lesions and promote tumor metastasis through...
Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation. Nat Commun. 2016;7:10883. Article CAS PubMed PubMed Central Google Scholar de Sena Brandine G, Smith AD. Falco: high-speed FastQC emulation for quality control of ...
(Fig.1h). Furthermore, miR-30d was more highly expressed in AJCC stage I PDAC than that in AJCC stage IV PDAC (Fig.1i). Further Kaplan–Meier analysis stratified by AJCC stage showed that high miR-30d expression predicted good prognosis of patients with AJCC stage I PDAC but not ...