cell cyclechromatindna replicationhela cellshistoneshybridizationin vitroDNA complementary to histone messenger RNAs was utilized to assay the in vitro transcripts from chromatin of G/sub 1/ and S phase HeLa S/sub 3/ cells for the presence of histone specific sequences. The complementary DNA was ...
0 36 Describe what happens during each stage of the cell cycle.[4'marks]Stage 1 DNA/chromosomes replicate/dulpicate mitochondria/ribosomes/sub-cellular structures increase in number or mitochondria/ribosomes/sub-cellular structures replicate___Stage 2 one set of chromosomes ispulled/moved to each...
hepatoma cells (subline N1S1-67) were monitored for the rates of transport of various substrates and for their incorporation into acid-insoluble material as a function of the age of cultures of randomly growing cells in suspension as well as during traverse of the cells through the cell cycle...
The typical eukaryotic cell cycle consists of four phases—G0/G1, S, G2 and M. During the first gap phase (G0/G1), the cell prepares for entry into a new round of replication and cell division, and ensures the availability of nutrients and frequently, also the cell size, are appropria...
Reversible cell cycle arrest mediated by a cAMP analog required the presence of CSF-1 for cells to initiate DNA synthesis, whereas cells released from an aphidicolin block at the G1/S boundary entered S phase in the absence of CSF-1. PGE2 or cAMP analogs did not block the initial ...
6d). Finally, the extracellular addition of recombinant La 1-375 to fusing osteoclasts dramatically increased osteoclast bone resorption (Fig. 6e). From these data, we conclude that targeting cell surface La bidirectionally regulates both osteoclast fusion and subsequent bone resorption....
Retinoblastoma is a childhood cancer of the retina initiated by the mutation of both copies of RB1 . The protein encoded by RB1, the tumour suppressor RB, regulates a signal transduction pathway controlling cell cycle progression that is disrupted in most cancers. Despite this knowledge, the iden...
关键词: n48520* --life sciences--radiation effects on animals-- vertebrates cell differentiation-- radiosensitivity effects embryos-- biological radiation effects cell cycle cell division dose-response relationships external irradiation mice molecular biology tissue cultures 年份: 1974 ...
Afatinib, an irreversible ErbB-family blocker, could improve the survival of advanced epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer patients (NSCLCm+). This phase II trial (NCT04201756) aimed to assess the feasibility of neoad
Sulforaphane (SF), a natural product from broccoli, is known to enhance detoxification of carcinogens and block initiation of chemically-induced carcinogenesis in animal models. Cell culture and xenograft studies suggest additional roles for SF, inhibiting growth of tumors, arresting the cell cycle and...