Among various molecules regulated by beta-catenin/Tcf, cyclin D1 is the most likely candidate for stimulation of the oncogenic pathway. The association between beta-catenin and cyclin D1 was investigated using clinical samples from colorectal cancers. Methods: The expression of beta-catenin and ...
Immunohistochemistry of cyclin D1 showed positive staining in 9 (37.5%) of the 24 parathyroid adenomas. The status of β-catenin, which has recently been identified as a regulator of cyclin D1 transcription, was examined by direct sequencing of exon 3 of the β-catenin gene and ...
BACKGROUND: beta-Catenin has dual functions: adhesive molucule and transcriptional activator. Subcellular accumulation of beta-catenin and subsequent formation of beta-catenin- Tcf/Lef-1 complexes, as well as c-myc and cyclin D1 genes which were recently defined as target genes of beta-catenin- ...
1. This study was aimed to quantitatively detect the levels of beta-catenin and cyclin D1 mRNA in various subgroups of acute myeloid leukemia(AML)and to analyze their potential relationship,so as to provide theoretical basis for exploring the role of Wnt/beta-catenin pathway in the pathogenesis...
Beta‘cateninand Cyclin D1.The Cyclin DI gene hadbeenshownto significantlyhigher after gene silencing ofBeta—catenin.RNAinterferenceBeta—cateninmadeUStounderstandbettertheroleof Beta’catenininWnt signalingthat played acriticalrolein mammaryglanddevelopment. ...
1.Expression of Beta-catenin,cyclinD1 and C-myc Genes in Hepatocellular Carcinoma;β-Catenin,cyclinD1及c-myc在肝细胞癌中的表达 2.The modulations ofbeta-cateninand caspase-3 levels were investigated in the KM mouse embryo following maternal treatme.用 RT-PCR 及蛋白质印迹技术,探测了过量维甲酸...
ObjectiveHead and neck squamous cell carcinoma (HNSCC) progression and metastasis have previously been associated with the activation of phosphatidylinositol 3-kinase-protein kinase B (PI3K-Akt) and Wnt signalling pathways, which lead to the activation of pro-proliferative genes, such as cyclin D1. ...
A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades. Wnt genes encode sm... H Clevers - 《Cell》 被引量: 8996发表: 2006年 Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Mutations in...
The target genes, c-myc and cyclin D1, were activated by beta-catenin in the hepatocytes. Our study suggests that mutant beta-catenin can promote cell proliferation and cell survival ability, but the stabilized beta-catenin alone is insufficient for completely oncogenic transformation....
[59], honokiol suppressed growth and clonogenicity of oral squamous cell carcinoma cells and the side population cells through the reduction of β-catenin and an increase in GSK-3α/β protein levels. Moreover, downstream targets of β-cateninvizc-Myc and cyclin D1 were also found to be ...