Results: Compared with noncancerous epithelium, beta-catenin and cyclin D1 were overexpressed (+) in 35 (50%) and 30 cases (43%), respectively. Cyclin D1 (+) was observed in 74% (26/35) of beta-catenin (+) cases, but only in 11% (4/35) of the beta-catenin (–) cases. ...
The status of β-catenin, which has recently been identified as a regulator of cyclin D1 transcription, was examined by direct sequencing of exon 3 of the β-catenin gene and immunohistochemistry of β-catenin protein, but neither mutation nor accumulation of β-catenin was detected in any of...
1. This study was aimed to quantitatively detect the levels of beta-catenin and cyclin D1 mRNA in various subgroups of acute myeloid leukemia(AML)and to analyze their potential relationship,so as to provide theoretical basis for exploring the role of Wnt/beta-catenin pathway in the pathogenesis...
The author investigated the rate of subcellular accumulation of beta-catenin and overexpression of c-myc and cyclin D1, and also investigated the association between them in the pulmonary adenocarcinomas. METHODS: Fifty-one surgically resected primary adenocarcinomas of the lung, including 11 bronchiolo...
Beta‘cateninand Cyclin D1.The Cyclin DI gene hadbeenshownto significantlyhigher after gene silencing ofBeta—catenin.RNAinterferenceBeta—cateninmadeUStounderstandbettertheroleof Beta’catenininWnt signalingthat played acriticalrolein mammaryglanddevelopment. ...
1)beta-cateninβ-catenin 1.Expression of Beta-catenin,cyclinD1 and C-myc Genes in Hepatocellular Carcinoma;β-Catenin,cyclinD1及c-myc在肝细胞癌中的表达 2.The modulations ofbeta-cateninand caspase-3 levels were investigated in the KM mouse embryo following maternal treatme.用 RT-PCR 及蛋白质...
ObjectiveHead and neck squamous cell carcinoma (HNSCC) progression and metastasis have previously been associated with the activation of phosphatidylinositol 3-kinase-protein kinase B (PI3K-Akt) and Wnt signalling pathways, which lead to the activation of pro-proliferative genes, such as cyclin D1. ...
The target genes, c-myc and cyclin D1, were activated by beta-catenin in the hepatocytes. Our study suggests that mutant beta-catenin can promote cell proliferation and cell survival ability, but the stabilized beta-catenin alone is insufficient for completely oncogenic transformation....
A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades. Wnt genes encode sm... H Clevers - 《Cell》 被引量: 8996发表: 2006年 Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Mutations in...
, it activates the TCF/LEF transcription factors, which act on a number of Wnt target genes, includingc-Myc,tcf1andcyclinD1. Mutations in this multiprotein complex, most commonly in APC, or inβ-catenin itself lead to dysregulated activation of these Wnt target genes, and subsequently result...