DATABASE BIOSIS [Online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1986, JOHNSON K G ET AL: " BETA LACTAMASES FROM ACTINOPOLYSPORA-HALOPHILA AN EXTREMELY HALOPHILIC ACTINOMYCETE " XP002356555 Database accession no. PREV198681105416 & ARCHIVES OF MICROBIOLOGY, vol. 143, no. 4, 1986...
Then we screened a library of 500,000 druglike compounds from the ZINC database to target this allosteric site using Glide and Schrödinger Suite. We identified five novel chemotypes, each containing a hydrophobic moiety that interacts with the hydrophobic pocket between the two helices and a ...
BLAD: a comprehensive database of widely circulated beta-lactamases. Bioinformatics. 2013;29(19):2515-6.Danishuddin M, Hassan Baig M, Kaushal L, Khan AU (2013) BLAD: a comprehensive database of widely circulated beta-lactamases. Bioinformatics 29: 2515-2516....
The amino acid sequences for 19 different types of beta-lactamases (ACT, CARB, CifA, CMY, CTX, FOX, GES, GOB, IMP, IND, KPC, LEN, OKP, OXA, OXY, SHV, TEM, NDM, and VIM) were obtained from the ARG-ANNOT database and were used to construct 19 HMM profiles, which were used to...
Virtual screening performed with 500,000 drug like compounds from the ZINC database showed that top scoring compounds interact with the hydrophobic pocket that forms between H10 and H11 helices and with the catalytically important Arg244 residue through pi-cation interactions. Discovery of novel ...
usingsequencesfromtheComprehensiveAntibioticResistanceDatabase(CARD).ThemodelswereusedasqueriesformetagenomeanalysisandrecoveredcontigsweresubsequentlyannotatedusingRAST.Accordingtoouranalysis;14metagenomesanalyzedcontainA;BandCbeta-lactamasegenes.ClassDgenes;however;wereidentifiedin11metagenomes.ThemostabundantwasclassC(...
databaseTEM-type beta-lactamasesantibiotic resistancemutant formsBeta-lactamases (EC 3.5.2.6) represent a superfamily containing more than 2000 members: it includes genetically and functionally different bacterial enzymes capable to degrade the beta-lactam antibiotics. Beta-lactamases of molecular class A ...
The MST shown inFigure 4establishes the relationship between the STs ofK. pneumoniae. In this case, the ST founder is ST504. Two isolates shared the sequence type ST2370. For the majority of theK. pneumoniaestrains, the ST was not found in the Pasteur MLST database. (See also the limitat...
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