An α-helix bundle is a small and compact protein fold always composed of more than 2 α-helices that typically run nearly parallel or antiparallel to each other. From:Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics,2017
Studies the amphipathic alpha-helix bundle organization of lipid-free chicken apolipoprotein A-I (apoA-I), the major protein component of plasma high-density lipoprotein (HDL). Unique structural properties of the chicken apoA-I; Depth of penetration of apoA-I into the surface monolayer of ...
Building a sophisticated protein nano-assembly requires a method for linking protein components in a predictable and stable structure. Most of the cross linkers available have flexible spacers. Because of this, the linked hybrids have significant structu
-bundle proteins. The first method characterizes the packing density ofindividual amino acids in helical proteins based on the van der Waals surface area occluded by surrounding atoms. We haverecently used this method to show that transmembrane helices pack more tightly, on average, than helices in...
Dimer-to-tetramer transformation: loop excision dramatically alters structure and stability of the ROP four alpha-helix bundle protein. The ROP loop excision mutant RM6 shows dramatic changes in structure and stability in comparison to the wild-type protein. Removal of the five amino acids ... MW...
Alpha-helical assembly of biologically active peptides and designed helix bundle pro- tein. Biopolymers. 34:481-488.Morii H, Honda S, Ohashi S, Uedaira H (1994) Alpha-helical assembly of biologically active peptides and designed helix bundle protein. Biopolymers 34:481-488...
Restored heptad pattern continuity does not alter the folding of a four-alpha-helix bundle. Nat Struct Biol 1994;1: 706 -716.Vlassi, M., Steif, C., Weber, P., Tsernoglou, D., Wilson, K.S., Hinz, H.J., Kokkinidis, M. Restored heptad pattern continuity does not alter the ...
Building block of the bundle protein; Composition of hydrophilic face; Dichotomy of structure; Stabilization of the bundle protein.SkalickyJackJ.GibneyBrianR.Journal of the American Chemical SocietySkalicky JJ, Gibney BR, Rabanal F, Urbauer RJB, Dutton PL, Wand AJ. Solution structure of a ...
PeptideDesignThe 57-peptide for four -helix bundle structure with alternating d-, l-, d-, and l-segments was synthesized, characterized, and compared with that of all l-segment--57-peptide by the aid of a 1-pyrenylalanine probe.doi:10.1016/0040-4039(95)02289-9Yuji Tanaka...
Using molecular dynamics (MD) simulations, we predicted the 3-dimensional structure of an artificially designed three-alpha-helix bundle, called A3, from a fully extended initial conformation, based on its amino acid sequence. The MD protocol enabled us to obtain the secondary, in 1.0 ns, as ...