HEIDECKE CLAUS-DIETER ET AL: " Alpha/beta-T cell receptor-directed therapy in rat allograft recipients: Long-term survival of cardiac allografts after pretreatment with R73 mAb is associated with upregulation of TH2-type cytokines " TRANSPLANTATION (BALTIMORE), vol. 61, no. 6, 1996, ...
The S protein of CoVs is responsible for receptor recognition, binding, and membrane fusion, and serves as the first key factor of host restriction by meditating viral entry. In different CoVs, the RBD can be located at the NTD or CTD in S1. For example, among the α-CoVs, CTD was...
Vanhoutteghem A, Londero T, Djian P, Ghinea N: Serial cultivation of chicken keratinocytes, a composite cell type that accumulates lipids and synthesizes a novel β-keratin. Differentiation. 2004, 72 (4): 123-137. 10.1111/j.1432-0436.2004.07204002.x. Article PubMed CAS Google Scholar Dall...
Intrathymic selection of NK1.1+ alpha/beta T cell antigen receptor (TCR)+ cells in transgenic...Presents a study which investigated the intrathymic selection of NK1.1+ alpha/betaCR+ thymocytes T cell antigen receptor (TCR), and spleen cells under the influence of a positive or negative ...
cell TFsNkx6-1(log2FC 2.18),Pax459,60(log2FC 9.48), andMafa61,62(log2FC 7.46). In addition to the rodent insulin-encoding genes (Ins1andIns2), top differentially expressed (DE) genes in βTC6 included a transmembrane receptor with unknown function (Tmem215), a regulator of beta cell...
英语翻译In conventional alphabeta T cells,the Tec family tyrosine kinase Itk is required for signaling downstream of the T cell receptor (TCR).Itk also regulates alphabeta T cell development,lineage commitment,and effector function.A well established feature of Itk(-/-) mice is their inability ...
Glucose homeostasis is dependent on functional pancreatic α and ß cells. The mechanisms underlying the generation and maturation of these endocrine cells remain unclear. We unravel the molecular mode of action of ISL1 in controlling α cell fate and
Early in their development, most T cells become committed to the expression of one, and only one, TCR alpha beta combination. How do T cells achieve this T... M Malissen,J Trucy,E Jouvin-Marche,... - 《Immunol Today》 被引量: 394发表: 1992年 Regulation of T cell receptor (TCR)...
The possible existence and distribution patterns of alpha/beta- and gamma/delta-TCR+ cells, which are important constituents of immune surveillance and act via the CD3+ cell complex have not yet been elucidated in the healthy and inflamed conjunctiva.Paraffin-embedded conjunctival specimens included 18...
Developing T cells in the thymus are subject to a screening process, through interactions with thymic stromal cells, from which T cells with appropriate T-cell receptors are selected. The recent generation of T-cell receptor transgenic mice and mice homozygous for disrupted T-cell receptor genes ...